{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:07:58Z","timestamp":1777784878493,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Septic shock is a clinical condition with high mortality (40%\u201370%) and morbidity. During septic shock, there is a significant release of cytokines and other inflammatory mediators that can cause damage to different organs, known as a \u201ccytokine storm.\u201d The cytokine storm can cause hypotension, tissue damage, metabolic acidosis, and renal failure. This clinical picture also seems to be confirmed in the context of Covid-19 patients. Hemoadsorption with CytoSorb represents an adjunctive therapy to attenuate the systemic inflammatory process and helps restore a balanced immune response. We present the clinical case of a 75-year-old man, admitted to our hospital with respiratory failure due to Sars-CoV-2 infection and secondary septic shock due to a sacral decubitus. On admission the patient presented with a clinical picture of mixed acidosis with high levels of lactate and inflammatory indexes. Simultaneously along with antibiotic therapy, we started hemoadsorption treatment with CytoSorb in combination with continuous venous-venous hemodiafiltration. At the end of the treatment the patient had recovered his vital functions and the infection was successfully treated. Use of the CytoSorb device in a Covid-19 positive patient was safe and well-tolerated. Early treatment with CytoSorb decreased interleukin 6 plasma levels and inflammatory indexes, resulting in earlier stabilization of homeostasis. This case report suggests that the use of CytoSorb could be a possible adjuvant therapy in patients with septic shock even when affected by Covid-19.<\/jats:p>","DOI":"10.1177\/03913988211016473","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T01:57:27Z","timestamp":1621216647000},"page":"1034-1038","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful use of CytoSorb in a Covid-19 patient with secondary septic shock due to a sacral decubitus infection"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-3298","authenticated-orcid":false,"given":"Flavia","family":"Pancani","sequence":"first","affiliation":[{"name":"Department of Emergency, Intensive Care Unit, San Donato Hospital, Arezzo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Pavani","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Unit, San Donato Hospital, Arezzo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Quacquarelli","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Unit, San Donato Hospital, Arezzo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Feri","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Unit, San Donato Hospital, Arezzo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"bibr1-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5085-0"},{"key":"bibr2-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"bibr3-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3906-y"},{"key":"bibr4-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1159\/000313773"},{"key":"bibr5-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"bibr6-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000114997.39857.69"},{"key":"bibr7-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318170b9a7"},{"key":"bibr8-03913988211016473","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.146321"},{"key":"bibr9-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1159\/000351206"},{"key":"bibr10-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1186\/cc14210"},{"key":"bibr11-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2588-1"},{"key":"bibr12-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1662-9"},{"key":"bibr13-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1159\/000502540"},{"key":"bibr14-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1159\/000509738"},{"key":"bibr15-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1159\/000511725."},{"key":"bibr16-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13864"},{"key":"bibr17-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000071"},{"key":"bibr18-03913988211016473","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.6615"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988211016473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988211016473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988211016473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:11Z","timestamp":1777491731000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988211016473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,16]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/03913988211016473"],"URL":"https:\/\/doi.org\/10.1177\/03913988211016473","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,16]]}}}