{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:10:55Z","timestamp":1777785055530,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Initiation of veno-arterial (VA) Extracorporeal Membrane Oxygenator (ECMO) is associated with severe complications. It is unknown whether these adverse consequences occur more often after initiations during out of hours service compared to working hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients receiving VA-ECMO for cardiogenic shock between 2009 and 2020 were categorized into a working hours group (between 8\u2009am and 5\u2009pm on weekdays) and an out of hours service group (between 5\u2009pm and 8\u2009am, or between Friday 5\u2009pm and Monday 8\u2009am). Primary outcome was all-cause mortality at 30\u2009days. Secondary outcomes included vascular complications (including limb ischemia and\/or bleeding), bloodstream infections and length of ICU stay. Propensity scores were used to adjust for potential confounding effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 250 patients (median (IQR) age 56 (42\u201364) years) receiving VA-ECMO (median duration 3.5 (1.0\u20139.0) days), 160 (64%) runs were initiated between 5\u2009pm and 8\u2009am whereas the remainder (36%) started during working hours. Characteristic did not differ between the working hours- and out of hours-group. By day 30, 37 (41.1%), and 68 (42.5%) patients in either group had died, respectively ( p\u2009=\u20090.831). VA-ECMO support duration and length of stay on the ICU did not differ significantly in both crude and adjusted analyses. More complications occurred during out of hours service ( p\u2009=\u20090.039).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Out of hours- versus working hours-initiation of VA-ECMO for cardiogenic shock was not associated with higher mortality, longer VA-ECMO support duration, or longer length of stay on the intensive care. Vascular complications were more common in the out of hours group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988211073344","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:30:01Z","timestamp":1644453001000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock during out of hours versus working hours is not associated with increased mortality"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-9925","authenticated-orcid":false,"given":"PS","family":"van der Wal","sequence":"first","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AO","family":"Kraaijeveld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-3521","authenticated-orcid":false,"given":"JJ","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LW","family":"van Laake","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Platenkamp","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LM","family":"de Heer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SA","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Department of Cardioanesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MMJ","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAJ","family":"Hermens","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OL","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DW","family":"Donker","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Cardiovascular and Respiratory Physiology Group, TechMed Centre, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Meuwese","sequence":"additional","affiliation":[{"name":"Departments of Intensive Care and Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"bibr1-03913988211073344","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.01"},{"key":"bibr2-03913988211073344","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.008"},{"key":"bibr3-03913988211073344","unstructured":"ELSO. 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