{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:21:05Z","timestamp":1783779665320,"version":"3.55.0"},"reference-count":5,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Though left ventricular assist devices (LVADs) are an increasingly common therapy for ACC\/AHA Stage D heart failure, the optimal medical therapy for patients with LVADs is not known. We sought to evaluate the safety and efficacy of angiotensin receptor neprilysin inhibitor (ARNi) therapy in our single center LVAD patient experience. We evaluated patients implanted with LVADs at Columbia University Irving Medical Center between August 2010 and May 2019, and who were treated with an ARNi for at least 3\u2009months. Thirty patients met this criteria. Eighteen (60%) patients transitioned to an ARNi from an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB), while all were on a beta blocker (BB) at the time of ARNi initiation. The primary outcome, NT-proBNP levels at time of initiation and 3 and 6\u2009month follow up, significantly decreased from a median of 1265\u2009pg\/mL at initiation to 750\u2009pg\/mL at 3\u2009months and 764\u2009pg\/mL at 6\u2009months ( p\u2009=\u20090.01). No significant change was seen in serum creatinine, BUN, or potassium levels.<\/jats:p>","DOI":"10.1177\/0391398821989066","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T01:25:38Z","timestamp":1611105938000},"page":"118-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin receptor neprilysin inhibitor use in patients with left ventricular assist devices: A single-center experience"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7971-2582","authenticated-orcid":false,"given":"Shudhanshu","family":"Alishetti","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Weill Cornell Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-8252","authenticated-orcid":false,"given":"Lorenzo","family":"Braghieri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L","family":"Jennings","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA"},{"name":"Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo C","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melana","family":"Yuzefpolskaya","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"bibr1-0391398821989066","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4965"},{"key":"bibr2-0391398821989066","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"bibr3-0391398821989066","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812851"},{"key":"bibr4-0391398821989066","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006696"},{"key":"bibr5-0391398821989066","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000957"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398821989066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0391398821989066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0391398821989066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:27Z","timestamp":1777491747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0391398821989066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/0391398821989066"],"URL":"https:\/\/doi.org\/10.1177\/0391398821989066","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]}}}