{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:09:26Z","timestamp":1777784966003,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the variations of Interleukin-6 (IL-6) in patients with SARS-CoV-2 infection treated with Tocilizumab (TCZ) alone or in association with hemoadsorption (HA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>An Intensive Care Unit (ICU) admitting mechanically ventilated patients with SARS-CoV-2 pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Four adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>\n                      We compared the blood values of IL-6, C-reactive protein (CRP) and of other biochemical variables including the PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      in two patients who received TCZ alone and in other 2 in whom it was associated with the HA (TCZ-HA) due to the presence of impending or established organ failures other than the lung. All variables were measured before, during and after the treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results:<\/jats:title>\n                    <jats:p>\n                      In all patients, the IL-6 increased during the treatment; after its termination, its values sharply decreased only in those treated also with HA; conversely, the CRP decreased in all patients; the PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      increased in three patients and remained stable in the remaining one. Both the TCZ and the HA were well tolerated; all patients were weaned from the mechanical ventilation and discharged from the hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Although the limited number of patients does not allow to draw firm conclusions, the increase of the IL-6 of can be ascribed to its displacement from cellular and soluble receptors, whereas its decrease is likely due to the scavenging effect exerted by the HA. Although the association TCZ-HA could be valuable in the treatment of the Cytokine Release Storm (CRS) associated with the SARS-CoV-2, the HA could be more effective as it neutralizes a wider panel of inflammatory mediators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398821989334","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T07:19:09Z","timestamp":1613200749000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of tocilizumab versus hemoadsorption combined with tocilizumab in patients with SARS-CoV-2 pneumonia: Preliminary results"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-4283","authenticated-orcid":false,"given":"Giorgio","family":"Berlot","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Pintacuda","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Paluzzano","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Scamperle","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Chillemi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Cattinara Hospital, Trieste, 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