{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:59:38Z","timestamp":1784811578166,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In patients treated for refractory cardiogenic shock (RCS) following acute myocardial infarction (AMI), predicting successful weaning from veno-arterial extracorporeal membrane oxygenation (VA ECMO) has important implications for decision-making and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective review of adult VA ECMO patients with RCS complicating AMI at our institution from 2010 to 2019. We evaluated use of peak troponin I as a predictor of successful decannulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-two patients were analyzed; mean age 61.1\u2009\u00b1\u20099.8\u2009years, 73% males, 62% presented with STEMI. Forty-five patients were successfully weaned (group I). Seventeen patients did not wean (group II); seven patients received a durable LVAD, 10 died. Patients from group I had significantly lower peak troponin I (89 vs 434\u2009ng\/mL, p\u2009=\u20090.0001). Receiver operating characteristic curves showed a peak troponin I cutoff of 400\u2009ng\/mL correctly classified patients by weaning status 90% of the time, with associated sensitivity of 71% and specificity of 98%. With each 50\u2009ng\/mL increase in troponin I, the likelihood of weaning decreased by 33%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Peak troponin I above 400\u2009ng\/mL may be helpful in predicting unsuccessful weaning from VA ECMO support for refractory cardiogenic shock following myocardial infarction and facilitate triage decisions regarding need for advanced therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0391398821991155","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T13:17:25Z","timestamp":1612531045000},"page":"68-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Peak troponin predicts successful weaning from VA ECMO in patients with acute myocardial infarction complicated by cardiogenic shock"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-8912","authenticated-orcid":false,"given":"Monique","family":"North","sequence":"first","affiliation":[{"name":"Minneapolis Heart Institute Foundation, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eckman","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Samara","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Chavez","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-1620","authenticated-orcid":false,"given":"Christian","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-4700","authenticated-orcid":false,"given":"Ross","family":"Garberich","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Hryniewicz","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"bibr1-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.034512"},{"key":"bibr2-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.095604"},{"key":"bibr3-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.04.010"},{"key":"bibr4-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.07.035"},{"key":"bibr5-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2019.1606277"},{"key":"bibr6-0391398821991155","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.08.05"},{"key":"bibr7-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.05.005"},{"key":"bibr8-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.07.016"},{"key":"bibr9-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.12.009"},{"key":"bibr10-0391398821991155","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122218"},{"key":"bibr11-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001220"},{"key":"bibr12-0391398821991155","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.023895"}],"container-title":["The International Journal of Artificial 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