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We report a case of a newborn boy with congenital diaphragmatic hernia (CDH) associated with ABO incompatibility and an inherited mild hemophilia A. Due to respiratory failure he needed ECMO on his first day of life. During ECMO an exchange transfusion was performed after an extensive hyperbilirubinemia had evolved. Thereafter severe bleeding occurred, and a very low factor VIII level was found causative for that. After factor VIII substitution bleeding was under control and the baby eventually could be weaned from ECMO, underwent corrective surgery, and recovered.<\/jats:p>","DOI":"10.1177\/0391398821994113","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T04:15:52Z","timestamp":1613621752000},"page":"243-246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["ABO incompatibility and mild factor VIII deficiency in the neonate: Not too much of a problem but a challenge on ECMO"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-5471","authenticated-orcid":false,"given":"Anna","family":"Hofer","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Kepler Universit\u00e4tsklinikum, MED CAMPUS III, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Prandstetter","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Kepler Universit\u00e4tsklinikum, MED CAMPUS III, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Kepler Universit\u00e4tsklinikum, MED CAMPUS III, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Leithner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Kepler Universit\u00e4tsklinikum, MED Campus IV, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"bibr1-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"bibr2-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0329"},{"key":"bibr3-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1078923"},{"key":"bibr4-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001709"},{"key":"bibr5-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.03.022"},{"issue":"10","key":"bibr6-0391398821994113","first-page":"1176","volume":"146","author":"Walsh-Sukys MC","year":"1992","journal-title":"Am J Dis Child"},{"key":"bibr7-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb02020.x"},{"key":"bibr8-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000061298.28953.7d"},{"key":"bibr9-0391398821994113","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14315"},{"key":"bibr10-0391398821994113","unstructured":"Konkle BA, Huston H, Fletcher NS, et al. 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