{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:11:08Z","timestamp":1779351068687,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    The use of acute mechanical circulatory support (MCS) has increased over the last decade. For patients with left-ventricular failure, an Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    (Abiomed, Danvers, MA) may be used to improve cardiac output. The purpose of this study is to describe Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    anticoagulation patterns and evaluate the safety and effectiveness of our protocol. This is a retrospective review of all adult patients who required at least 24\u2009h of Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    support and received a heparin-based purge solution. In total, 109 patients were included in the final analysis. The most common indication for Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    device insertion was cardiogenic shock (76%) with the remaining patients receiving a device for a high-risk procedures; typically coronary artery bypass grafting or percutaneous coronary intervention. A total of 9 thrombotic events occurred among 8 (7%) patients and 50 bleeding events occurred among 43 (39%) patients, with the most common classification being BARC 3a (60%). A univariate analysis revealed that patients were more likely to bleed if they were less than 65\u2009years old, had an indication of cardiogenic shock for Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , inserted the device peripherally, were on dual antiplatelet therapy, or had an intra-aortic balloon pump prior to Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    insertion, the latter of which was confirmed with a multivariate analysis (OR 2.5 [1.072\u20135.830]; p\u2009=\u20090.034). For those monitored by anti-Xa, the presence of two or more values greater than 0.40\u2009IU\/mL was a risk factor for bleeding ( p\u2009=\u20090.037). Our study identifies risk factors for bleeding in patients receiving temporary MCS with an Impella\n                    <jats:sup>\u00ae<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/03913988221082686","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T01:23:30Z","timestamp":1647221010000},"page":"550-559","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Antithrombotic management for Impella\n                    <sup>\u00ae<\/sup>\n                    temporary ventricular assist devices: An analysis of an academic health-system experience"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-7291","authenticated-orcid":false,"given":"Olivia","family":"Iskaros","sequence":"first","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Ahuja","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Arnouk","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Toy","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-1917","authenticated-orcid":false,"given":"Tyler","family":"Lewis","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Altshuler","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deane","family":"Smith","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Merchan","sequence":"additional","affiliation":[{"name":"New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"key":"bibr1-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-019-01837-6"},{"key":"bibr2-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035566"},{"key":"bibr3-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3791307"},{"key":"bibr4-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020922542"},{"key":"bibr5-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001004"},{"key":"bibr6-03913988221082686","unstructured":"Abiomed. Anticoagulation therapy with impella heparin infusion, https:\/\/www.heartrecovery.com\/resources\/downloads\/product-update-anti-coagulation-therapy-with-impella-heparin-infusion (2020, accessed June 17, 2021)."},{"key":"bibr7-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"bibr8-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1177\/0897190018757148"},{"key":"bibr9-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020944831"},{"key":"bibr10-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.04.003"},{"key":"bibr11-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1093\/ehjacc\/zuab051"},{"key":"bibr12-03913988221082686","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163710"},{"key":"bibr13-03913988221082686","volume":"17","author":"Chieffo A","year":"2021","journal-title":"Eur Heart J"},{"key":"bibr14-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708454"},{"key":"bibr15-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu298"},{"key":"bibr16-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817083"},{"key":"bibr17-03913988221082686","doi-asserted-by":"publisher","DOI":"10.1177\/1060028021994621"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988221082686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988221082686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988221082686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:51Z","timestamp":1777491771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988221082686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,13]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1177\/03913988221082686"],"URL":"https:\/\/doi.org\/10.1177\/03913988221082686","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,13]]}}}