{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:12:06Z","timestamp":1777785126797,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In deceased donor kidney transplantation (KT), the use of hypothermic machine perfusion (HMP) has been acquiring the status of best practice in the pre-transplant management of kidney grafts. Two types of HMP are currently available, oxygenated HMP and non-oxygenated HMP. However, data on the real clinical impact of oxygenation on KT outcome are still heterogeneous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Retrospective study on a cohort of 103 patients transplanted with a single kidney graft that was managed either with end-ischemic oxygenated (O\n                      <jats:sub>2<\/jats:sub>\n                      group, Waves Machine, n\u2009=\u200951, 49.5%) or non-oxygenated HMP (no-O\n                      <jats:sub>2<\/jats:sub>\n                      group, Life Port Kidney Transporter Machine, n\u2009=\u200952, 50.5%), during the period January 2016\u2013December 2020. Oxygenation was performed at pO\n                      <jats:sub>2<\/jats:sub>\n                      21%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median cold ischemia time was 29\u2009h:40\u2009min [IQR 26\u2009h:55\u2009min\u201331\u2009h:10\u2009min] and the prevalence of grafts from extended criteria donors (ECD) was 46.7%, with a median kidney donor profile index (KDPI) of 72 [41\u201394]. The study groups were homogeneous in terms of recipient characteristics, ischemia times and donor characteristics. O\n                      <jats:sub>2<\/jats:sub>\n                      and no-O\n                      <jats:sub>2<\/jats:sub>\n                      groups showed comparable outcomes in terms of delayed graft function (O\n                      <jats:sub>2<\/jats:sub>\n                      vs no-O\n                      <jats:sub>2<\/jats:sub>\n                      , 21.5% vs 25%, p\u2009=\u20090.58), vascular (0.2% vs 0.2%, p\u2009&gt;\u20090.99) and urologic (13.7% vs 11.5%, p\u2009=\u20090.77) complications, and episodes of graft rejection (11.7% vs 7.7%, p\u2009=\u20090.52). At 1\u2009year follow up, even creatinine serum levels were comparable between the groups (1.27 mg\/dL [1.09 and 1.67] vs 1.4 mg\/dL [1.9\u20131.78], p\u2009=\u20090.319), with similar post-transplant trend ( p\u2009=\u20090.870). No significant benefit was either observed in ECD or KDPI\u2009&gt;\u200960 subgroups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Oxygenation at pO\n                      <jats:sub>2<\/jats:sub>\n                      21% during HMP seems not to significantly enhance the KT outcomes in terms of postoperative complications or graft function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988221107946","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T01:21:06Z","timestamp":1656120066000},"page":"666-671","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["PO\n                    <sub>2<\/sub>\n                    21% oxygenated hypothermic machine perfusion in kidney transplantation: Any clinical benefit?"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-4580","authenticated-orcid":false,"given":"Riccardo","family":"Pravisani","sequence":"first","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Baccarani","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Molinari","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Cherchi","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Terrosu","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Avital","sequence":"additional","affiliation":[{"name":"Department of Surgery A, Soroka University Medical Center, Beer Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-8007","authenticated-orcid":false,"given":"Burcin","family":"Ekser","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Luigi","family":"Adani","sequence":"additional","affiliation":[{"name":"Liver-Kidney Transplantation Unit, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"bibr1-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13364"},{"issue":"3","key":"bibr2-03913988221107946","volume":"3","author":"Tingle SJ","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr3-03913988221107946","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081221"},{"key":"bibr4-03913988221107946","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.918997"},{"key":"bibr5-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03757-8"},{"key":"bibr6-03913988221107946","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080993"},{"key":"bibr7-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32411-9"},{"key":"bibr8-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0949"},{"key":"bibr9-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13858"},{"key":"bibr10-03913988221107946","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2019.0139"},{"key":"bibr11-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318266401c"},{"key":"bibr12-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003051"},{"key":"bibr13-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74839-7"},{"key":"bibr14-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62979-9"},{"key":"bibr15-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab108"},{"key":"bibr16-03913988221107946","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001077"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988221107946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988221107946","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988221107946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:57Z","timestamp":1777491777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988221107946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/03913988221107946"],"URL":"https:\/\/doi.org\/10.1177\/03913988221107946","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]}}}