{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:10:07Z","timestamp":1777785007012,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100017695","name":"health commission of hunan province","doi-asserted-by":"publisher","award":["grant no. A2016001"],"award-info":[{"award-number":["grant no. A2016001"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of continuous renal replacement therapy (CRRT) modalities with regional sodium citrate anticoagulation (RCA) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study was conducted at the paediatric intensive care unit of Hunan Children\u2019s Hospital in China. Medical records of paediatric patients hospitalised for RCA-CRRT between April 2017 and March 2021 were reviewed. Patients received continuous venovenous haemodialysis, continuous venovenous haemofiltration (CVVH), or continuous venovenous haemodiafiltration (CVVHDF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients on continuous venovenous haemodialysis ( n\u2009=\u20092) were excluded because of their small sample size. The remaining participants were divided into CVVH and CVVHDF groups; 80 patients received CRRT, with 40 and 62 sessions in the CVVH and CVVHDF groups, respectively. The filtre lifespan was longer in the CVVHDF group than in the CVVH group (median value [interquartile range]; 47 [15]\u2009hours vs. 35 [17.5]\u2009hours; p\u2009=\u20090.029). Compared with the CVVHDF group, the hazard ratio for filtre lifespan in the CVVH group was 3.023 (95% confidence interval 1.820\u20135.023, p\u2009&lt;\u20090.001). There were no significant differences in ionised calcium levels of the circuits between the two groups at different time points ( p\u2009&lt;\u20090.05). Metabolic alkalosis, hyperlactataemia, hypocalcaemia, and hypercalcaemia occurred in both groups, with metabolic alkalosis being the most common complication. No patients in either group experienced sodium citrate accumulation or hypernatraemia. Inter-group differences in the incidence of these complications were not statistically significant ( p\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results suggest that CVVHDF is a better option for RCA-CRRT than CVVH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988221115447","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:42:15Z","timestamp":1659055335000},"page":"997-1005","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of different modalities of continuous renal replacement therapy with regional sodium citrate anticoagulation in paediatric patients"],"prefix":"10.1177","volume":"45","author":[{"given":"Jie","family":"He","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshe","family":"Cao","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayan","family":"Kang","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-0031","authenticated-orcid":false,"given":"Xinping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"bibr1-03913988221115447","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.18618"},{"key":"bibr2-03913988221115447","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"bibr3-03913988221115447","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.350"},{"key":"bibr4-03913988221115447","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-014-0160-2"},{"key":"bibr5-03913988221115447","first-page":"1217","volume":"100","author":"Xianghong Y","year":"2020","journal-title":"Natl Med J 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