{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:20:08Z","timestamp":1785417608965,"version":"3.56.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Oxygenator exchange during extracorporeal membrane oxygenation (ECMO) is a life-threatening procedure. D-dimer has been used to predict oxygenator failure, but it is a parameter used a few days before oxygenator exchange. This study investigated parameters before and immediately after ECMO initiation that predict oxygenator exchange.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a single-center, retrospective study of 28 patients who received veno-venous ECMO with heparin\/silicone-coated polypropylene oxygenator (NSH-R HPO-23WH-C; Senko Medical Inc., Tokyo, Japan), due to acute respiratory failure, from April 2015 to March 2020. Clinical data before ECMO initiation and during the first 3\u2009days on ECMO were compared between the patients with oxygenator exchange (exchange group) and those without oxygenator exchange (non-exchange group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nine (32%) patients required oxygenator exchange. The exchange group had significantly higher white blood cell count (WBC) (16,944\u2009\u00b1\u20092423\/\u00b5L vs 10,342\u2009\u00b1\u20091442\/\u00b5L, p\u2009&lt;\u20090.05) and Acute Physiology and Chronic Health Evaluation (APACHE) II score (31\u2009\u00b1\u20095 vs 25\u2009\u00b1\u20098, p\u2009&lt;\u20090.05) before ECMO initiation than the non-exchange group. The partial pressure of oxygen at the outlet of the oxygenator (PO\n                      <jats:sub>2 outlet<\/jats:sub>\n                      ) and activated partial thromboplastin time (aPTT) during the first 3\u2009days on ECMO were significantly lower in the exchange group than in the non-exchange group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      High WBC and APACHE II score before ECMO initiation, low PO\n                      <jats:sub>2 outlet<\/jats:sub>\n                      , and aPTT during the first 3\u2009days on ECMO were associated with oxygenator exchange during veno-venous ECMO. These parameters could be used to avoid unexpected oxygenator exchange.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988221118382","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T01:17:56Z","timestamp":1660871876000},"page":"927-935","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Early predictors of oxygenator exchange during veno-venous extracorporeal membrane oxygenation: A retrospective analysis"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-3211","authenticated-orcid":false,"given":"Nao","family":"Umei","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Nippon Medical School, Tokyo, Japan"},{"name":"Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Ichiba","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nippon Medical School, Tokyo, Japan"},{"name":"Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Genda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nippon Medical School, Tokyo, Japan"},{"name":"Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mase","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nippon Medical School, Tokyo, Japan"},{"name":"Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nippon Medical School, Tokyo, Japan"},{"name":"Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"bibr1-03913988221118382","volume":"7","author":"Makdisi G","year":"2015","journal-title":"J Thorac Dis"},{"key":"bibr2-03913988221118382","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1103720"},{"key":"bibr3-03913988221118382","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c190006"},{"issue":"1","key":"bibr4-03913988221118382","volume":"1","author":"Jaffer IH","year":"2015","journal-title":"J Thromb 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