{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:07:23Z","timestamp":1787018843821,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      New dialysis membranes with new properties are being developed to improve efficacy and tolerance. The hemocompatibility of a polymeric biomaterial is influenced by the layer of water at the blood membrane interface. The new dialyzer TORAY NV-U\n                      <jats:sup>\u00ae<\/jats:sup>\n                      has a membrane Hydrolink\u2122, designed to suppress platelet adhesion and to improve the hemocompatibility. Until now, there is no experience in online hemodiafiltration (OL-HDF). The objective of the present study is to evaluate the efficacy of this new membrane in OL-HDF therapy compared to another membrane commonly used. Other objectives are to evaluate the inflammatory response, hemodynamic tolerance, and the anticoagulation regimes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This is a prospective pilot study performed in five anuric patients receiving OL-HDF. For 1\u2009month patients were kept with their usual dialyzer FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (FMC). Subsequently, the dialyzer was changed to TORAY NV-U\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (Hydrolink\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) for 1\u2009month. In the last dialysis session of each dialyzer, blood tests were performed to evaluate inflammation and depurative capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We did not find differences in medium size removal molecules and convective volume: FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      : 31\u2009\u00b1\u20099\u2009l per session and Hydrolink\u2122 30\u2009\u00b1\u20098\u2009l; p\u2009=\u20090.7); \u03b22microglobulin reduction ratio (RR) FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      FMC 83\u2009\u00b1\u20093%; Hydrolink\u2122 79\u2009\u00b1\u20094; p\u2009=\u20090.14; Myoglobin RR FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      FMC 72\u2009\u00b1\u20097%; Hydrolink\u2122 76\u2009\u00b1\u20094; p\u2009=\u20090.28. We did not find differences in inflammation parameters: serum IL6 with FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      6.0\u2009\u00b1\u20094.2\u2009pg\/mL; Hydrolink\u2122 7.6\u2009\u00b1\u20095.0\u2009pg\/mL; p\u2009=\u20090.3. During all sessions with the two dialyzers there was adequate plasmatic filling, reaching 85 % filling. All patients had \u201cgood\u201d dialyzer status in all dialysis sessions with TORAY NV-U\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , while the dialyzer status with FX1000\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was \u201cgood\u201d in 20% of the sessions, \u201cmedium\u201d in 30%, and \u201cdirty\u201d in the remaining 50% dialysis sessions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The new dialyzer Hydrolink\u2122, TORAY NV-U\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is not inferior to perform OL-HDF compared to dialyzers usually used for this therapy, and could allow decrease heparin doses. Further studies with a bigger sample size and longer follow-up will answer if Hydrolink improves inflammation and assess a better hemodynamic tolerance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988241274735","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T06:50:24Z","timestamp":1726901424000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Depurative capacity toward medium molecules of the dialyzer Toray NV-U\n                    <sup>\u00ae<\/sup>\n                    Hydrolink\u2122: A new hydrophilic membrane to perform online hemodiafiltration"],"prefix":"10.1177","volume":"47","author":[{"given":"Maria","family":"Kislikova","sequence":"first","affiliation":[{"name":"Nephrology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-7924","authenticated-orcid":false,"given":"Almudena","family":"Vega","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Verde","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Abad","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital el Bierzo, Ponferrada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vaca","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Acosta","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Bascu\u00f1ana","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Mijailova","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coraima","family":"Nava","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-9870","authenticated-orcid":false,"given":"Miguel","family":"Villa","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Goicoechea","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"bibr1-03913988241274735","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.V92267","volume":"9","author":"Foley RN","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"bibr2-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-018-1059-9"},{"key":"bibr3-03913988241274735","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000608"},{"key":"bibr4-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1159\/000518652"},{"key":"bibr5-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2006.00134.x"},{"key":"bibr6-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12939"},{"key":"bibr7-03913988241274735","volume":"13","author":"H\u00f6rl WH","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"bibr8-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1163\/092050610X488269"},{"key":"bibr9-03913988241274735","doi-asserted-by":"publisher","DOI":"10.14340\/spp.2014.05C0002"},{"key":"bibr10-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.13092"},{"key":"bibr11-03913988241274735","volume":"24","author":"Branger B","year":"1988","journal-title":"Kidney Int Suppl"},{"key":"bibr12-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90266-2"},{"key":"bibr13-03913988241274735","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040844"},{"key":"bibr14-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2021.07.049"},{"key":"bibr15-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-017-0139-2"},{"key":"bibr16-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00200.x"},{"key":"bibr17-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1159\/000079170"},{"key":"bibr18-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1177\/089686080602600510"},{"key":"bibr19-03913988241274735","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12454"},{"key":"bibr20-03913988241274735","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051234"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988241274735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988241274735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988241274735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:41:10Z","timestamp":1777491670000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988241274735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/03913988241274735"],"URL":"https:\/\/doi.org\/10.1177\/03913988241274735","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]}}}