{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:44:23Z","timestamp":1783183463586,"version":"3.54.6"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2017\/27\/B\/ST7\/03029"],"award-info":[{"award-number":["2017\/27\/B\/ST7\/03029"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,3]]},"abstract":"\n Significant changes in pre-dialytic partial pressure of CO\n 2<\/jats:sub>\n (pCO\n 2<\/jats:sub>\n ) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO\n 2<\/jats:sub>\n and plasma bicarbonate concentration (C\n Bic<\/jats:sub>\n ) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO\n 2<\/jats:sub>\n , pH, and C\n Bic<\/jats:sub>\n in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V\n E<\/jats:sub>\n ) and net acid generation rate (G\n H<\/jats:sub>\n ) for each interdialytic interval. Dialysances of bicarbonate and dissolved CO\n 2<\/jats:sub>\n were also estimated independently for each HD session. The error of the model compared to the pre-dialytic data of C\n Bic<\/jats:sub>\n and pCO\n 2<\/jats:sub>\n significantly decreased when V\n E<\/jats:sub>\n and G\n H<\/jats:sub>\n were estimated piecewise throughout the week. To fit the data, V\n E<\/jats:sub>\n changed from 3.9\u2009\u00b1\u20091.0\u2009mL\/min before HD1, to 3.8e1\u2009mL\/min after HD1, 3.6\u2009\u00b1\u20091.0\u2009mL\/min after HD2, and 3.9\u2009\u00b1\u20091.1\u2009mL\/min after HD3 (\n p<\/jats:italic>\n \u2009<\u20090.05). G\n H<\/jats:sub>\n changes after each session were not statistically significant. V\n E<\/jats:sub>\n values strongly correlated with pre-dialytic pCO\n 2<\/jats:sub>\n (Spearman\u2019s \u03c1\u2009=\u2009\u22120.97), but G\n H<\/jats:sub>\n only weakly correlated with pre-dialytic C\n Bic<\/jats:sub>\n (\u03c1\u2009=\u2009\u22120.30). Acid-base equilibrium is extremely sensitive to respiratory regulation. When attempting to predict the evolution of pCO\n 2<\/jats:sub>\n a C\n Bic<\/jats:sub>\n during the HD cycle, changes in the respiration parameters must be accounted for by the model, at the risk of a significant loss of prediction accuracy.\n <\/jats:p>","DOI":"10.1177\/03913988251314664","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:24:44Z","timestamp":1738283084000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-783X","authenticated-orcid":false,"given":"Mauro","family":"Pietribiasi","sequence":"first","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-3472","authenticated-orcid":false,"given":"John K","family":"Leypoldt","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wieliczko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-7930","authenticated-orcid":false,"given":"Malgorzata","family":"Debowska","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Malyszko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Waniewski","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"528","article-title":"Beyond bicarbonate: complete acid-base assessment in patients receiving intermittent hemodialysis","volume":"32","author":"Marano M","year":"2017","unstructured":"Marano M, Marano S, Gennari FJ. Beyond bicarbonate: complete acid-base assessment in patients receiving intermittent hemodialysis. Nephrol Dial Transplant 2017; 32: 528\u2013533.","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69355-7_58"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282104"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.162"},{"key":"e_1_3_2_6_2","volume-title":"Pulmonary aspects of dialysis patientsReplacement of Renal Function by Dialysis","author":"Broe ME","year":"1996","unstructured":"Broe ME, De Lins RL, De Backer WA. Pulmonary aspects of dialysis patients. In: Replacement of Renal Function by Dialysis, 1996, Springer, Dordrecht."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-585-36947-1_41"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12714"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100523"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/03913988241268026"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/03913988231179233"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v10.i1.16"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v33.i3.10"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v33.i3.20"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2024.10.002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.1.91"},{"key":"e_1_3_2_17_2","volume-title":"Physical chemistry, composition of blood, hematology, somatometric data","author":"Lentner C","year":"1984","unstructured":"Lentner C (ed.) Physical chemistry, composition of blood, hematology, somatometric data. Geigy Scientific Tables. 8th ed. Ciba-Geigy Limited, Basel, 1984.","edition":"8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159748"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2021.07.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa142.P1061"},{"key":"e_1_3_2_21_2","first-page":"858","article-title":"Aortic body chemoreceptor responses to changes in PCO2 and PO2 in the cat","volume":"47","author":"Lahiri S","year":"1979","unstructured":"Lahiri S, Mulligan E, Nishino T, et al Aortic body chemoreceptor responses to changes in PCO2 and PO2 in the cat. 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