{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:45:49Z","timestamp":1782585949161,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Hemodialysis can significantly prolong the survival of uremia patients, but uremia and long-term hemodialysis can also cause complications. This study aimed to compare the clinical efficacy between the menostat mesylate and sodium citrate as anticoagulants in patients receiving CRRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The clinical data of 80 patients with uremic cerebral hemorrhage in our hospital from January 2020 to October 2022 were collected and randomly divided into observation (nelostat anticoagulation,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40) and control (citrate and sodium anticoagulation,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40) groups. Physiological parameters, CRRT filter life, coagulation function index, activated whole blood coagulation time (ACT), anticoagulation efficiency rate, and incidence of adverse reactions were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The physiological index, coagulation function index, ACT value, and anticoagulation efficiency were higher in the observation group than in the control group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). The observation group also demonstrated a longer CRRT filter life and lower incidence of adverse reactions than those in the control group (both\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Naphlimostat mesylate demonstrated a good anticoagulant effect and was safe for use in CRRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988251318901","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:25:27Z","timestamp":1780557927000},"page":"443-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical efficacy of anticoagulants in patients with uremic cerebral hemorrhage receiving continuous renal replacement therapy"],"prefix":"10.1177","volume":"49","author":[{"given":"Zhenhua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, General Hospital of the Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9049-5585","authenticated-orcid":false,"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Hubei No\ufeff. 3 People\u2019s Hospital of Jianghan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/03913988231172786"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591231171271"},{"key":"e_1_3_2_4_2","first-page":"464","article-title":"Compliance to phosphorus-controlled diet and influencing factors in patients with uremic blood purification","volume":"44","author":"Wu YJ","year":"2023","unstructured":"Wu YJ, Zhou B, Zhang JM. Compliance to phosphorus-controlled diet and influencing factors in patients with uremic blood purification. Jilin Med Sci 2023; 44: 464\u2013467.","journal-title":"Jilin Med Sci"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031224"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-024-01945-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2022.12.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1463_22"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.352"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoleng.2022.106816"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002076"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1442537"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-063856"},{"key":"e_1_3_2_14_2","first-page":"1148","article-title":"Retrospective study of the efficacy and safety of naphlimostat mesylate anticoagulation on continuous renal replacement therapy in patients treated in surgical intensive care units","volume":"43","author":"Zhang Y","year":"2022","unstructured":"Zhang Y, Yin N, Ding HS. Retrospective study of the efficacy and safety of naphlimostat mesylate anticoagulation on continuous renal replacement therapy in patients treated in surgical intensive care units. World Clin Med 2022; 43: 1148\u20131153.","journal-title":"World Clin Med"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.03.017"},{"key":"e_1_3_2_16_2","first-page":"3704","article-title":"Analysis of factors influencing secondary stress injury in patients with cerebral hemorrhage","volume":"51","author":"Wang K","year":"2022","unstructured":"Wang K, Chen Y, Tang WY. Analysis of factors influencing secondary stress injury in patients with cerebral hemorrhage. Chongqing Med 2022; 51: 3704\u20133748.","journal-title":"Chongqing Med"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6140"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.postharvbio.2022.111965"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2022.02.014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trc.2022.103655"},{"key":"e_1_3_2_21_2","article-title":"SARS-CoV-2 infection and ENaC activity are both inhibited by nafamostat applied apically on human airway epithelial cells in air-liquid interface culture","volume":"203","author":"Kirkpatrick L","year":"2021","unstructured":"Kirkpatrick L, Millard J, Hall R, et al. SARS-CoV-2 infection and ENaC activity are both inhibited by nafamostat applied apically on human airway epithelial cells in air-liquid interface culture. Am J Respir Crit Care Med 2021; 203: A3782.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.08.087"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03078-z"},{"key":"e_1_3_2_24_2","first-page":"801","article-title":"Anticoagulant use of nafamostat mesilate in continuous renal replacement therapy","volume":"33","author":"Beicun SZ","year":"2018","unstructured":"Beicun SZ, Zhang L. Anticoagulant use of nafamostat mesilate in continuous renal replacement therapy. 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