{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:03:38Z","timestamp":1777784618303,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"InCor-FMUSP internal fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Liver machine perfusion (MP) has emerged as a promising organ preservation modality. Recent studies have shown that the addition of the kidneys to the circuit improves the biochemical environment and could benefit liver preservation. The aim of this study was to explore the technical and anatomical feasibility of\n                      <jats:italic>en bloc<\/jats:italic>\n                      liver\u2013pancreas\u2013kidney MP. We also examined the safety of ex vivo perfusion with a nonoxygen carrier solution and its effects on acid\u2013base and metabolic parameters using this novel multivisceral perfusion platform.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Five multivisceral allografts, including liver, pancreas, duodenum, and kidney, were perfused for 4\u2009h with acellular perfusate. Hemodynamic and laboratory data were evaluated throughout the experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No system failure was reported. There were minimal changes in the acid\u2013base parameters during the experiment. Lactate and glucose levels were stable throughout hypothermic perfusion. There was a mild increase in liver function parameters in the last hour of hypothermic perfusion. No changes in creatinine levels were observed throughout the study. The urine output increased steadily during the experiment, with an average of 155.6\u2009mL\/h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We described an innovative multivisceral MP technique that could be further used as a platform for physiological studies and targeted therapeutic interventions. Further investigations are necessary to evaluate this ex vivo perfusion technique and provide insights into the feasibility of hypothermic acellular multivisceral MP in clinical scenarios.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988251330084","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T03:17:58Z","timestamp":1748056678000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An innovative model of\n                    <i>en bloc<\/i>\n                    liver\u2013pancreas\u2013kidney preservation via ex vivo hypothermic acellular machine perfusion"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-4221","authenticated-orcid":false,"suffix":"Jr.","given":"Ruy J","family":"Cruz","sequence":"first","affiliation":[{"name":"Department of Surgery, Gastrointestinal Rehabilitation and Transplant Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio FH","family":"Galvao","sequence":"additional","affiliation":[{"name":"Research Division, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Benicio","sequence":"additional","affiliation":[{"name":"Research Division, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000500"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2023.07.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02165.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.11.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-014-0813-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24954"},{"issue":"2","key":"e_1_3_2_9_2","first-page":"1663","article-title":"Combined kidney\u2011liver perfusion enhances the proliferation effects of hypothermic perfusion on liver grafts via upregulation of IL\u20116\/Stat3 signaling","volume":"20","author":"Li J","year":"2019","unstructured":"Li J, Jia J, He N, et al. 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