{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:59:08Z","timestamp":1790873948665,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The project of medical staff technical elevation of the Xijing Hospital of the Fourth Medical University","award":["2023XJSZ06"],"award-info":[{"award-number":["2023XJSZ06"]}]},{"name":"the discipline promotion project of the Xijing Hospital of the Fourth Medical University","award":["XJZT24LY26"],"award-info":[{"award-number":["XJZT24LY26"]}]},{"DOI":"10.13039\/100014718","name":"innovative research group project of the national natural science foundation of china","doi-asserted-by":"publisher","award":["82070699"],"award-info":[{"award-number":["82070699"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is a lack of consensus regarding the optimal anticoagulation strategy for continuous renal replacement therapy (CRRT) in patients with hyperlactataemia and a high risk of bleeding. The purpose of this study was to evaluate the safety and efficacy of the commonly used anticoagulation methods for CRRT in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The present study included patients with hyperlactataemia (\u2a7e2\u2009mmol\/L) and a high risk of bleeding who underwent CRRT at Xijing Hospital from 2020 to 2024. Filter lifespan, bleeding complications, blood infusion and adverse effects were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The present study included a total of 53 patients who underwent no anticoagulation (NA)-CRRT, 32 patients who underwent nafamostat mesylate (NM)-CRRT and 47 patients who underwent regional citrate anticoagulation (RCA)-CRRT. The filter lifespan was significantly different among the three groups (NA\u2009=\u200925\u2009h (IQR\u2009=\u200918.4, 34.5), NM\u2009=\u200941\u2009h (IQR\u2009=\u200924.0, 54.3) and RCA\u2009=\u200936\u2009h (IQR\u2009=\u200923.0, 53.5),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 30-day mortality rate was significantly higher in the NA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Furthermore, the incidence of bleeding complications (43.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and blood transfusions (28.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) were higher in the NA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The utilization of either NM or RCA has the potential to extend the filter lifespan and may be associated with a reduced risk of bleeding. These findings suggest that NM and RCA may be safe and effective for CRRT patients with hyperlactataemia and a high risk of bleeding if careful monitoring and timely adjustment are employed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988251360552","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T10:24:44Z","timestamp":1755339884000},"page":"639-652","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Different anticoagulation methods for continuous renal replacement therapy in patients with hyperlactataemia and a high risk of bleeding"],"prefix":"10.1177","volume":"48","author":[{"given":"Chunyan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"},{"name":"Xi\u2019an Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"},{"name":"Xi\u2019an Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"},{"name":"Xi\u2019an Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"},{"name":"Xi\u2019an Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-8511","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-2336","authenticated-orcid":false,"given":"Ming","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"},{"name":"Department of Nephrology, 986 Hospital, Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3184-5"},{"issue":"8","key":"e_1_3_3_3_2","first-page":"777","article-title":"Safety and efficacy of regional citrate anticoagulation in continuous renal replacement therapy in the presence of acute kidney injury after hepatectomy","volume":"30","author":"Zhang C","year":"2018","unstructured":"Zhang C, Lin T, Zhang J, et al Safety and efficacy of regional citrate anticoagulation in continuous renal replacement therapy in the presence of acute kidney injury after hepatectomy. 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