{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:05:00Z","timestamp":1777784700125,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nitto Foundation","award":["JOSE205112"],"award-info":[{"award-number":["JOSE205112"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K19467"],"award-info":[{"award-number":["24K19467"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This study aimed to investigate the association of exposure below various thresholds of mean arterial pressure (MAP), pump flow rates, and hemoglobin levels during cardiopulmonary bypass (CPB) with cardiac surgery-associated acute kidney injury (CSA-AKI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Adult patients undergoing cardiac surgery with CPB at a university hospital between April 2015 and August 2023 were included. The primary outcome was CSA-AKI within 7\u2009days postoperatively. The primary exposures were the area under the threshold (AUT) of MAP, pump flow rate, and Hb during CPB. A multivariable logistic regression using covariates selected via Lasso regularization estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We finally analyzed 333 patients, of which 156 patients (46.8%) developed CSA-AKI. The AUT of hemoglobin, but not those of MAP and pump flow rate, was associated with CSA-AKI. The lower the threshold, the stronger the association (&lt;8\u2009g\/dL, aOR\u2009=\u20091.132 per 10\u2009g\/dL\u2009\u00d7\u2009min, 95% CI\u2009=\u20091.036\u20131.243,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007; &lt;9\u2009g\/dL, aOR\u2009=\u20091.048, 95% CI\u2009=\u20091.013\u20131.086,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007; and &lt;10\u2009g\/dL, aOR\u2009=\u20091.027, 95% CI\u2009=\u20091.007\u20131.048,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hemoglobin levels during CPB below 8.0\u2009g\/dL were associated with CSA-AKI, while MAP and pump flow rates indicated no such association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988251365814","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T11:19:51Z","timestamp":1756120791000},"page":"741-750","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of exposure below various thresholds of hemodynamic parameters during cardiopulmonary bypass with acute kidney injury"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7107-7008","authenticated-orcid":false,"given":"Takumi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Clinical Engineering, Nagoya City University Hospital, Nagoya, Japan"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 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