{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:05:19Z","timestamp":1777784719954,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Achieving optimal unloading in patients with left ventricular assist devices (LVADs) is associated with improved outcomes but remains unattainable in some cases. We retrospectively reviewed 33 patients with a HeartMate 3 LVAD who underwent speed optimization with concomitant echocardiography and right heart catheterization for inadequate left ventricular (LV) unloading between January 2016 and December 2023. Patients were stratified based on left ventricular transmural pressure (LVTMP) into two groups: LVTMP \u2a7d7\u2009mmHg and LVTMP &gt;7\u2009mmHg using a median split approach. Pulmonary capillary wedge pressure (PCWP) decreased in both groups with increased LVAD speed; however, the mean PCWP change per 100 rpm was significantly smaller in patients with LVTMP \u2a7d7\u2009mmHg (\u22120.50 vs \u22120.99\u2009mmHg per 100 rpm,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003). Comparative analysis demonstrated LVTMP\u2019s superiority over established RV markers, with the strongest interaction effect for predicting speed optimization response. Changes in cardiac output were similar between the two groups. In univariate analysis, multiple hemodynamic parameters were significantly associated with reduced LVTMP, including right atrial pressure (OR\u2009=\u20091.27,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.036), TPG (OR\u2009=\u20091.25,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.037), DPG (OR\u2009=\u20091.69,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012), and PAPi (OR\u2009=\u20090.35,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.019).LVTMP, as a surrogate for true LV preload, particularly in the context of RV failure, may offer predictive value for the success or failure of LV unloading with LVAD speed optimization.\n                  <\/jats:p>","DOI":"10.1177\/03913988251388558","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T06:33:23Z","timestamp":1763102003000},"page":"852-857","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Left ventricular transmural pressure: A predictor of left ventricle unloading in continuous flow left ventricular assist devices"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-8892","authenticated-orcid":false,"given":"Rayan","family":"Yousefzai","sequence":"first","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Cathey","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed A.","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khush","family":"Patel","sequence":"additional","affiliation":[{"name":"J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1831-0447","authenticated-orcid":false,"given":"Hatem","family":"Alansari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Suarez","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Houston Methodist, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Hakan","family":"Akay","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Houston Methodist, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-8554","authenticated-orcid":false,"given":"Mahwash","family":"Kassi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Bhimaraj","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh N.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Tedford","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashrith","family":"Guha","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610426"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006067"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005094"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.01.1962"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.03.021"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001575"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001088"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1201\/b18401"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.05.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4273"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-018-0726-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.6.435"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.6.H2385"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1023549"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.08.003"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988251388558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988251388558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988251388558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:41:40Z","timestamp":1777491700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988251388558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/03913988251388558"],"URL":"https:\/\/doi.org\/10.1177\/03913988251388558","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}