{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:05:23Z","timestamp":1777784723135,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Coupled plasma filtration and adsorption (CPFA) is a non-selective extracorporeal technique designed to modulate systemic inflammation through plasma filtration combined with resin-based adsorption. While preclinical data were promising, randomized trials in septic shock yielded conflicting results and raised safety concerns, leading to its discontinuation. Nonetheless, selected patients might benefit from CPFA when adequately delivered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective, single-center observational study of 36 critically ill patients treated with CPFA between 2019 and 2022. A total of 56 CPFA sessions were analyzed, evaluating clinical indications, plasma-treated volume (VPT), hemodynamic changes, and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The main indication was sepsis (75%), followed by rhabdomyolysis and intoxications (8% each). Most patients received one to two sessions, with a mean duration of 9\u2009\u00b1\u20091\u2009h and a VPT of 10,103\u2009\u00b1\u20094275\u2009mL. Survival at 72\u2009h and 28\u2009days was 85% and 61%, respectively, with no early deaths. Patients achieving a VPT \u2a7e18% of estimated plasma volume had better 28-day survival (81% vs 42%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03), although they had lower initial severity scores. A non-significant trend toward vasopressor reduction was observed. No major adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cohort, CPFA was feasible and safe, with possible hemodynamic and survival benefits when a sufficient plasma-treated volume was reached. Patient selection and optimized treatment delivery appear crucial. However, the retrospective design and lack of a control group limit definitive conclusions. Future research should focus on more effective and targeted extracorporeal strategies for immune modulation in critically ill patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988251391998","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T08:39:19Z","timestamp":1763109559000},"page":"871-877","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The last dance of coupled plasma filtration adsorption (CPFA): Clinical outcomes, challenges, and perspectives in multiple organ support therapy"],"prefix":"10.1177","volume":"48","author":[{"given":"Cristian","family":"Pedreros-Rosales","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"},{"name":"Nephrology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Musalem","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Alvarado Livacic","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n, Chile"},{"name":"Biomedical Research Unit, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"M\u00fcller-Ortiz","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"},{"name":"Nephrology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-9997","authenticated-orcid":false,"given":"Gonzalo","family":"Ram\u00edrez-Guerrero","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000490234"},{"issue":"2","key":"e_1_3_2_3_2","first-page":"153","article-title":"Uso cl\u00ednico de la plasmafiltraci\u00f3n acoplada con adsorci\u00f3n","volume":"42","author":"Pedreros-Rosales C","year":"2022","unstructured":"Pedreros-Rosales C, M\u00fcller-Ortiz H, Colomina-Climent F. Uso cl\u00ednico de la plasmafiltraci\u00f3n acoplada con adsorci\u00f3n. Rev Nefrol Dial Traspl 2022; 42(2): 153\u2013165.","journal-title":"Rev Nefrol Dial Traspl"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2022.08.008"},{"issue":"6","key":"e_1_3_2_5_2","first-page":"695","article-title":"Coupled plasma filtration adsorption (CPFA) versus emofiltrazione continua con regime intermittente di alti volumi (pHVHF) nel trattamento dello shock settico: uno studio pilota","volume":"26","author":"Lentini P","year":"2009","unstructured":"Lentini P, Cruz D, Nalesso F, et al. Coupled plasma filtration adsorption (CPFA) versus emofiltrazione continua con regime intermittente di alti volumi (pHVHF) nel trattamento dello shock settico: uno studio pilota. 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