{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:21:51Z","timestamp":1783052511923,"version":"3.54.6"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Septic shock is a life-threatening condition. Prolonged intermittent high-volume hemofiltration (HVHF) has been used as a hemodynamic support and immunomodulation strategy for patients with severe septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied a retrospective cohort of patients with severe septic shock who received HVHF, evaluating the response to this therapy and the factors associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We analyzed 63 patients with severe septic shock (age 62.8\u2009\u00b1\u200913.8\u2009years, 57.1% female, maximum SOFA 16.1\u2009\u00b1\u20093.4). Mortality was significantly associated with male sex, medical pathology at admission, chronic critical illness condition, elevated SOFA, and high doses of norepinephrine at the end of HVHF. Patients whose HVHF was performed within 24\u2009h after surgery had lower mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.025). Norepinephrine dose decreased significantly with HVHF (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038). Mortality in our study was 73%, significantly lower than the predicted mortality by SOFA score: 80%\u201390% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HVHF could facilitate the management of critically ill patients with severe septic shock, especially women and surgical patients. It would allow for immunomodulation and hemodynamic support, providing time to control infection and improve the poor prognosis for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261422328","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:05:47Z","timestamp":1771999547000},"page":"193-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged intermittent high-volume hemofiltration in severe septic shock"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-3686","authenticated-orcid":false,"given":"Rodrigo A","family":"Sep\u00falveda","sequence":"first","affiliation":[{"name":"Department of Nephrology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Red de Salud UC-Christus, Santiago, Chile"},{"name":"Nephrological Procedures Unit, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi\u00e1n","family":"Juanet","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Red de Salud UC-Christus, Santiago, Chile"},{"name":"Nephrological Procedures Unit, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P","family":"Huidobro","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Red de Salud UC-Christus, Santiago, Chile"},{"name":"Nephrological Procedures Unit, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Nephrological Procedures Unit, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Kattan","sequence":"additional","affiliation":[{"name":"Department of Intensive Medicine, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Roessler","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Red de Salud UC-Christus, Santiago, Chile"},{"name":"Nephrological Procedures Unit, Red de Salud UC-Christus, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119835043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103044"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.628302"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000335"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12581"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2181-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-017-0967-4"},{"issue":"1","key":"e_1_3_2_11_2","article-title":"High-volume haemofiltration for sepsis in adults","volume":"1","author":"Borthwick EM","year":"2017","unstructured":"Borthwick EM, Hill CJ, Rabindranath KS, et al. 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