{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:23:08Z","timestamp":1783052588468,"version":"3.54.6"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Dialysis-related amyloidosis (DRA) is a serious complication in chronic kidney disease patients on long-term dialysis, caused by \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -microglobulin (\u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG) accumulation, and remains challenging owing to the growing dialysis population and extended treatment duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      To develop and evaluate stereocomplex poly(methyl methacrylate) (PMMA) adsorbent fibers with optimized cross-sectional and nanoporous structures for efficient, selective \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG removal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Structured PMMA fibers were fabricated via dry-wet spinning. The adsorption performance of optimized fibers was evaluated with serum containing \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG and other solutes, using scanning electron microscopy (SEM), three-dimensional transmission electron microscopy (3D-TEM), and time-of-flight secondary ion mass spectrometry (TOF-SIMS). Pressure loss simulations compared fiber- and bead-packed columns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fibers with 12\u201315\u2009nm pores exhibited maximal \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG adsorption. Cross-shaped fibers exhibited the highest blood-contact surface area and adsorption capacity. A thin surface-dense layer (&lt;0.1\u2009\u03bcm) improved \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG diffusion while limiting albumin uptake. TOF-SIMS confirmed uniform \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG penetration, with albumin confined near the fiber surface. Adsorption exceeded 50% for mid-weight proteins (~52\u2009kDa), including IL-6, \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      -microglobulin (\u03b1\n                      <jats:sub>1<\/jats:sub>\n                      -MG), and TNF-\u03b1. Pressure loss simulations showed that fiber-packed columns had lower resistance than bead-packed columns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Optimized cross-shaped PMMA fibers enable efficient, selective \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -MG removal and favorable flow dynamics for hemoperfusion therapies targeting mid-weight uremic toxins.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261429904","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:13:04Z","timestamp":1773893584000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cross-shaped nanoporous poly(methyl methacrylate) fibers for selective adsorption of \u03b2\n                    <sub>2<\/sub>\n                    -microglobulin and other middle-molecular-weight proteins"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8469-5593","authenticated-orcid":false,"given":"Hiroaki","family":"Fujieda","sequence":"first","affiliation":[{"name":"Toray Industries, Inc., Advanced Materials Research Laboratories, Otsu, Shiga, Japan"},{"name":"Toray Medical Co Ltd, Blood Purification Division, Chuo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Osuka","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc., Advanced Materials Research Laboratories, Otsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-3574","authenticated-orcid":false,"given":"Masaru","family":"Nakada","sequence":"additional","affiliation":[{"name":"Toray Research Center Inc, Research and Development Planning Department, Otsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Kanda","sequence":"additional","affiliation":[{"name":"Toray Research Center Inc, Research and Development Planning Department, Otsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc., Advanced Materials Research Laboratories, Otsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc., Advanced Materials Research Laboratories, Otsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc., Advanced Materials Research Laboratories, Otsu, Shiga, 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