{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:27:26Z","timestamp":1777865246686,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The conventional triple immunosuppressive regimen administered following heart transplantation typically comprises a calcineurin inhibitor, an antiproliferative agent, and corticosteroids. Everolimus has emerged as a viable alternative to calcineurin inhibitors. This study aims to evaluate the immunosuppressive efficacy and adverse effect profile of everolimus when introduced after the first post-transplant year, in comparison to continued calcineurin inhibitor therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 90 heart transplant recipients under regular follow up. Patients were categorized into two groups: those who maintained calcineurin inhibitor therapy beyond the first year post-transplant (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45), and those who transitioned to everolimus after the first year (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45). The groups were compared in terms of rejection incidence and side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Following the treatment modification, the everolimus group showed a significant improvement in serum urea and creatinine levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Rejection rates after the first year were found to be similar between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Everolimus provides effective immunosuppression with a lower rate of side effects.It demonstrates a favorable impact on renal function without increasing the risk of rejection.The first year may be recommended as the optimal timing, considering both safe wound healing and the risk of rejection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261429909","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:43:08Z","timestamp":1775295788000},"page":"235-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of everolimus with calcineurin inhibitors in maintenance immunosuppression"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-2343","authenticated-orcid":false,"given":"Abdulkadir","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-114X","authenticated-orcid":false,"given":"Do\u011fan Emre","family":"Sert","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-069X","authenticated-orcid":false,"given":"\u00dcmit","family":"Kervan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-4004","authenticated-orcid":false,"given":"Sinan Sabit","family":"Kocabeyoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8038-145X","authenticated-orcid":false,"given":"Enis Burak","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Gevrek","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeref Alp","family":"K\u00fc\u00e7\u00fcker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cardiovascular Surgery, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"\u00d6zatik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"\u015eener","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cardiovascular Surgery, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2021.12.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022171"},{"key":"e_1_3_2_5_2","first-page":"535983","article-title":"Efficacy and safety of low-dose cyclosporine with everolimus and steroids in de novo heart transplant patients: a multicentre, randomized trial","volume":"2011","author":"Zuckermann A","year":"2011","unstructured":"Zuckermann A, Wang SS, Ross H, et al. 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