{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:11Z","timestamp":1779688991710,"version":"3.53.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Gelatin\/sericin hydrogels (GSH) were developed as bioactive wound-care biomaterials due to their favorable biocompatibility, moisture retention, and inherent bioactivity. Their physicochemical characteristics and wound-healing efficacy were systematically evaluated. The hydrogels were prepared by blending gelatin and sericin, followed by crosslinking, and characterized using Fourier-transform infrared spectroscopy (FTIR) and High-resolution scanning electron microscopy (HRSEM), along with antimicrobial activity, MTT cytocompatibility assay, histological (H&amp;E) analysis, and in vivo zebrafish wound-healing studies. FTIR confirmed successful integration of gelatin and sericin through characteristic amide bands and enhanced hydrogen bonding, while HRSEM revealed a uniform porous architecture with interconnected microstructures. The GSH exhibited pronounced antimicrobial activity, with inhibition zones of 34.5\u2009\u00b1\u2009.5\u2009mm against\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    and 10.2\u2009\u00b1\u20090.4\u2009mm against\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    , comparable to those of the gentamicin controls. Cytocompatibility was confirmed by &gt;90% cell viability in MTT assays, and in vivo zebrafish models demonstrated significantly enhanced wound closure (72% by day 5) compared with untreated controls (38%). Collectively, these findings highlight the promising potential of GSH as a biocompatible, antimicrobial, and pro-healing hydrogel for wound management applications.\n                  <\/jats:p>","DOI":"10.1177\/03913988261437251","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:43:51Z","timestamp":1776314631000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication and biological evaluation of a bioactive gelatin\u2013sericin hydrogel for infected wound healing"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-5673","authenticated-orcid":false,"given":"Senthil","family":"Rethinam","sequence":"first","affiliation":[{"name":"Nano-Bioproducts Research Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4353-465X","authenticated-orcid":false,"given":"Felin Paul","family":"Paulraj","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-0946","authenticated-orcid":false,"given":"Geoffrey Sundar","family":"Edwin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9931-1769","authenticated-orcid":false,"given":"Geetha Sravanthy","family":"Pelluru","sequence":"additional","affiliation":[{"name":"Nano-Bioproducts Research Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6362"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/gels9050381"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17101243"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.03.026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA07531E"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics18010074"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/gels10030188"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-012-0816-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101306"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080359"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400362"},{"key":"e_1_3_2_14_2","first-page":"4158","article-title":"Interaction pathways and structure\u2013chemical transformations of alginate gels in physiological environments","volume":"11","author":"Martina U","year":"2019","unstructured":"Martina U, Miroslava P, Jiri C, et al. Interaction pathways and structure\u2013chemical transformations of alginate gels in physiological environments. Biomacromolecules 2019; 11: 4158\u20134170.","journal-title":"Biomacromolecules"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124494"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma17174199"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02315-9"},{"key":"e_1_3_2_18_2","first-page":"114916","article-title":"Biofunctional silk sericin hydrogels: a versatile platform with potential for tissue healing and regeneration","volume":"225","author":"Anabela V","year":"2025","unstructured":"Anabela V, Viviana R, Rosa AR, et al. Biofunctional silk sericin hydrogels: a versatile platform with potential for tissue healing and regeneration. Colloid Surf B Biointer 2025; 225: 114916.","journal-title":"Colloid Surf B Biointer"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15110322"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2025.2590033"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-024-01020-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-025-04352-z"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988261437251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988261437251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988261437251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:16:00Z","timestamp":1779686160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988261437251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/03913988261437251"],"URL":"https:\/\/doi.org\/10.1177\/03913988261437251","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]}}}