{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:00:09Z","timestamp":1780898409602,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["SZWJ2024a060"],"award-info":[{"award-number":["SZWJ2024a060"]}],"id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Hemoperfusion (HP) is proposed to remove middle molecules inadequately cleared by conventional dialysis, yet its comprehensive benefits across multiple uremic complications remain underexplored. In this propensity score-matched retrospective cohort study of 184 maintenance hemodialysis patients, we compared outcomes between 35 patients receiving regular weekly HP and 35 receiving irregular HP (\u2a7d3 times\/year) over 2\u2009years. The regular HP group achieved similar blood pressure control (80.0% vs 74.3%) but with significantly lower antihypertensive medication burden (score: 1.9 vs 3.1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). They also demonstrated superior mineral bone disease management, with lower iPTH (288.5 vs 412.3\u2009pg\/mL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and phosphate levels (1.52 vs 1.83\u2009mmol\/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002), higher composite target achievement (62.9% vs 42.9%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.048), and reduced need for phosphate binders and active vitamin D. Notably, regular HP dramatically reduced uremic pruritus requiring medication (gabapentin: 14.3% vs 80.0%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and dialysis-related encephalopathy (2.9% vs 20.0%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.024). No increased safety risks were observed. Regular HP offers comprehensive benefits, improving management of hypertension and mineral bone disease while dramatically reducing pruritus and encephalopathy risk, all with a favorable safety profile.\n                  <\/jats:p>","DOI":"10.1177\/03913988261448210","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:06:33Z","timestamp":1778839593000},"page":"363-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted benefits of regular hemoperfusion in maintenance hemodialysis: A propensity score-matched study"],"prefix":"10.1177","volume":"49","author":[{"given":"Shan","family":"Wu","sequence":"first","affiliation":[{"name":"Blood Purification Center, Affiliated Suzhou Municipal Hospital of Anhui Medical University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Blood Purification Center, Affiliated Suzhou Municipal Hospital of Anhui Medical University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Su","sequence":"additional","affiliation":[{"name":"Blood Purification Center, Affiliated Suzhou Municipal Hospital of Anhui Medical University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Blood Purification Center, The First People\u2019s Hospital of Yongkang, Affiliated to Hangzhou Medical College, Yongkang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blood Purification Center, The Fifth Medical Center of PLA General Hospital, Poisoning Treatment Center of PLA, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-8025","authenticated-orcid":false,"given":"Xishan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Blood Purification Center, Affiliated Suzhou Municipal Hospital of Anhui Medical University, Suzhou, China"},{"name":"Blood Purification Center, The First People\u2019s Hospital of Yongkang, Affiliated to Hangzhou Medical College, Yongkang, China"},{"name":"Blood Purification Center, The Fifth Medical Center of PLA General Hospital, Poisoning Treatment Center of PLA, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12030253"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab202"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00924.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(96)00040-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl455"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000414"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.189"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.454"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0266-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00787.2016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327131"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.08.016"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000534906"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000527953"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04009-w"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.10.023"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01666"},{"key":"e_1_3_3_19_2","article-title":"Hemoperfusion adsorbents for removal of common toxins in liver and kidney failure: recent progress, challenges, and prospects","volume":"37","author":"Wu S","year":"2025","unstructured":"Wu S, Yue P, Ma Y, et al. Hemoperfusion adsorbents for removal of common toxins in liver and kidney failure: recent progress, challenges, and prospects. Adv Mater 2025; 37: e2305152.","journal-title":"Adv Mater"},{"key":"e_1_3_3_20_2","first-page":"1","article-title":"Randomized control study on hemoperfusion combined with hemodialysis versus standard hemodialysis: effects on middle-molecular-weight toxins and uremic pruritus","volume":"2022","author":"Zhao D","year":"2022","unstructured":"Zhao D, Wang Y, Wang Y, et al. Randomized control study on hemoperfusion combined with hemodialysis versus standard hemodialysis: effects on middle-molecular-weight toxins and uremic pruritus. Blood Purif 2022; 2022: 1\u201311.","journal-title":"Blood Purif"},{"key":"e_1_3_3_21_2","first-page":"1","article-title":"Shanghai HP-HD Consensus Group. Hemoperfusion in maintenance hemodialysis patients","volume":"2022","author":"Lu W","year":"2022","unstructured":"Lu W, Jiang G; Shanghai HP-HD Consensus Group. 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