{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:50:58Z","timestamp":1791186658514,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K15796"],"award-info":[{"award-number":["JP24K15796"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Large extracorporeal blood volume causes intradialytic hemodynamic instability. However, the impact of blood returning from the extracorporeal circuit on systemic tissue oxygenation after hemodialysis (HD) remains inadequately studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This single-center prospective observational study included 33 patients who underwent HD and clinical data from 81 HD sessions. Post-HD, blood is pumped at a rate of 120\u2009mL\/min for 3\u2009min as the extracorporeal circuit is rinsed. Cerebral and hepatic regional oxygenation saturation (rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) levels were monitored from the end of HD to 5\u2009min post-HD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were significant increases in cerebral and hepatic rSO\n                      <jats:sub>2<\/jats:sub>\n                      levels at 5\u2009min post-HD compared with those post-HD (cerebral rSO\n                      <jats:sub>2<\/jats:sub>\n                      ; 52.6\u2009\u00b1\u20097.3 vs 54.2\u2009\u00b1\u20097.1, hepatic rSO\n                      <jats:sub>2<\/jats:sub>\n                      ; 63.0%\u2009\u00b1\u200910.9% vs 68.8%\u2009\u00b1\u200910.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). %Changes in hepatic rSO\n                      <jats:sub>2<\/jats:sub>\n                      at 5\u2009min post-HD were significantly greater than those in cerebral rSO\n                      <jats:sub>2<\/jats:sub>\n                      (3.4%\u2009\u00b1\u20095.7% vs 9.9%\u2009\u00b1\u20096.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and were independently and significantly associated with ultrafiltration rate (standardized coefficient: 0.217), mean blood pressure post-HD (\u22120.374), and oxygen saturation post-HD (0.258).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We demonstrated that the impact of blood returning post-HD on changes in tissue oxygenation may have been greater in the liver than in the brain.<\/jats:p>\n                  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