{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:51:01Z","timestamp":1791186661576,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation of Hunan Province of China","award":["2021JJ40297"],"award-info":[{"award-number":["2021JJ40297"]}]},{"name":"2024 Haidian Hospital Research Project-Youth Project","award":["KYQ2024007"],"award-info":[{"award-number":["KYQ2024007"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Coronary artery calcification (CAC) is a predictor of poor survival and cardiovascular outcomes in patients with end-stage renal disease. This study assessed the risk factors for vascular calcification in patients on maintenance hemodialysis (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In total, 71 patients who underwent HD in our hospital from January 2022 to September 2022 were enrolled. The general clinical data and laboratory results of the patients were collected and the CAC score was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CAC occurred in 41\/71 patients (57.75%) in the study. Baseline characteristics including primary disease, height, weight, blood pressure, dialysis duration, smoking history, and comorbid hypertension rates did not significantly differ between patients with and without CAC. Compared with the findings in the calcification group, the non-calcification group had significantly higher fibrinogen (4.2 (3.7\u20135.3) vs 3.6 (3.1\u20134.5);\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01) and ferritin levels (194.0 (85.2\u2013288.0) vs 44.9 (18.0\u2013170.5);\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and lower calcium levels (2.2 (2.0\u20132.3) vs 2.3 (2.2\u20132.4);\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and red blood cell counts (3.0\u2009\u00b1\u20090.8 vs 3.4\u2009\u00b1\u20090.7;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). In logistic regression analysis, the risk of CAC was predicted by diabetes (odds ratio (OR)\u2009=\u20091.82, 95% confidence interval (CI)\u2009=\u20091.37\u201328.11;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02) and the red blood cell count (OR\u2009=\u20092.99, 95% CI\u2009=\u20091.05\u20135.02;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04). Based on receiver operating characteristic curve analysis, the area under the curve of the red blood cell count for predicting the risk of CAC was 0.66 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02), using a clinical diagnostic cutoff of 2.99 (sensitivity, 75.6%; specificity, 56.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The incidence rate of CAC was high in patients on HD. Diabetes and elevated red blood cell count emerged as independent risk factors for predicting the risk of CAC in patients on HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261465532","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:07:32Z","timestamp":1784606852000},"page":"757-764","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for coronary artery calcification in patients on hemodialysis"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-9041","authenticated-orcid":false,"given":"Fan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of nephrology, Beijing Haidian Hospital, Haidian Section of Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiya","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-7748","authenticated-orcid":false,"given":"Xun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of nephrology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1021075"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.175"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30183-3"},{"key":"e_1_3_3_5_2","article-title":"TRPC5 channel inhibition protects podocytes in puromycin\u2013aminonucleoside induced nephrosis models","volume":"8","author":"Zhou Y","year":"2021","unstructured":"Zhou Y, Kim C, Pablo JLB, et al. 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