{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:46:33Z","timestamp":1791740793613,"version":"4.3.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs) into a calcium alginate scaffold for sustained drug release and cell delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NICNPs demonstrated comparable encapsulation efficiencies across formulations (44.97%\u2009\u00b1\u20097.23%, 41.54%\u2009\u00b1\u20094.70%, and 44.67%\u2009\u00b1\u20098.81% for 1%, 3%, and 5% loading, respectively), with biphasic sustained drug release over 168\u2009h. All hydrogels supported ASC viability; under oxidative stress, NICNP hydrogels significantly improved cell survival compared with ASC-only hydrogels. In vitro, NICNP\u2013ASC constructs markedly reduced LPS-induced cytokines (TNF-\u03b1, IL-6, and IL-1\u03b2). In vivo, in a rat SCI model, NICNP\u2013ASC hydrogels significantly reduced lesion volume and enhanced gray and white matter preservation compared to other formulations and the control group. Alginate hydrogel incorporating ASCs and niraparib-loaded chitosan nanoparticles at 5% w\/w drug loading (HY\u2013ASC\u2013NICNPs-5) demonstrated maximal efficacy, showing robust parenchymal bridging, dense myelin preservation, and angiogenesis. Behavioral recovery improved significantly, with BBB scores highest in HY\u2013ASC\u2013NICNPs-5 at both 4 and 8\u2009weeks. ELISA confirmed elevated neurotrophic factors and antioxidant enzymes alongside reduced inflammatory cytokines in NICNP\u2013ASC groups, particularly in the 5% formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Overall, these dual-functional hydrogel systems created a pro-regenerative microenvironment, attenuated secondary injury cascades, and restored hindlimb motor function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261470323","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:20:40Z","timestamp":1791454840000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-therapeutic niraparib-loaded chitosan nanoparticle\u2013alginate hydrogel with adipose-derived stromal cells promotes functional and histological recovery after spinal cord injury"],"prefix":"10.1177","author":[{"given":"Haibo","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xidian Group Hospital, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6446-7354","authenticated-orcid":false,"given":"Yunfei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Gansu Provincial Maternity and Child-care Hospital (Gansu Province Central Hospital), Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Jalili","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences, Isfahan University, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.698736"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-018-9462-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-021-00167-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm5018237"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.01.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5c00519"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174405"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2194532"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.51847\/fHjZDJorr4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.353485"},{"issue":"1","key":"e_1_3_2_13_2","article-title":"Radiation-induced neuroinflammation: a potential protective role for poly (ADP-ribose) polymerase inhibitors?","volume":"4","author":"Gutierrez-Quintana R","year":"2022","unstructured":"Gutierrez-Quintana R, Walker DJ, Williams KJ, et al. 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