{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:24:13Z","timestamp":1794097453394,"version":"4.8.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The pediatric patient group undergoing left ventricular assist device (LVAD) implantation is small and unique. Many efforts have been made to prolong survival. In our study, we aimed to evaluate the effects of levosimendan administration on postoperative outcomes in pediatric patients undergoing LVAD implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This retrospective single-center study included patients under 18\u2009years of age who underwent LVAD implantation. Patients with INTERMACS class 1 were excluded from the study. Patients were divided into two groups: Group A (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914), who received levosimendan preoperatively in addition to standard inotropic therapy, and Group B (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200917), who received standard inotropic therapy alone. Levosimendan was administered at a dose of 0.1\u2009\u00b5g\/kg\/min for 72\u2009h without a loading bolus. Primary outcomes were early right ventricular failure and in-hospital mortality. Secondary outcomes included the need for right ventricular assist, late right ventricular failure, and changes in organ function as assessed by liver and kidney function tests. Safety points for drug administration were defined as arrhythmia, hypotension, and sudden arrest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline characteristics (except LVEDD), ventricular function, and vasoactive inotropic scores were similar between the groups. No significant difference was observed in terms of early right ventricular failure, in-hospital mortality, or length of hospital stay. The rates of need for right ventricular assist and late right ventricular failure were comparable. Improvements in organ function were observed in both groups; significantly greater reductions in aspartate aminotransferase and alanine aminotransferase levels were recorded in the levosimendan group. No treatment-limiting side effects were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preoperative levosimendan administration seems to be safe in pediatric LVAD candidates and is associated with improved end-organ function, although it has not demonstrated superiority over standard inotropic therapy in terms of preventing right ventricular failure or reducing mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261473042","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:24:52Z","timestamp":1787135092000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of levosimendan before left ventricular assist device implantation in pediatric patients"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-2343","authenticated-orcid":false,"given":"Abdulkadir","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-4004","authenticated-orcid":false,"given":"Sinan Sabit","family":"Kocabeyoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-069X","authenticated-orcid":false,"given":"\u00dcmit","family":"Kervan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-4999","authenticated-orcid":false,"given":"Mehmet","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-8434","authenticated-orcid":false,"given":"Bekir Bo\u011fa\u00e7han","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8038-145X","authenticated-orcid":false,"given":"Enis Burak","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Kasapo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeki","family":"\u00c7atav","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.10.042"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.06.015"},{"issue":"2","key":"e_1_3_2_4_2","first-page":"423","article-title":"The right ventricle in cardiac surgery, a perioperative perspective: II. 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