{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:12Z","timestamp":1792787712292,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nipro Corporation","id":[{"id":"https:\/\/ror.org\/035649778","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"abstract":"<jats:p>\n                    Efficient removal of middle-to-large molecules, such as \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin (\u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -MG, 33\u2009kDa), is essential for mitigating long-term complications in patients undergoing hemodiafiltration (HDF). However, objective evaluation of diafilter performance requires standardized laboratory systems that can reproduce clinical transport characteristics while monitoring albumin leakage. This study established an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    experimental system utilizing recombinant \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -MG to evaluate post-dilution on-line HDF. Two configurations were compared: Circuit#1, featuring an auxiliary pump at the blood outlet, and Circuit#2, where the pump was removed to optimize flow regulation. Results demonstrated that Circuit#1 significantly deviated from clinical benchmarks due to internal pressure accumulation. Conversely, Circuit#2 successfully mirrored clinical trends, showing a strong positive correlation between \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -MG removal and albumin leakage. Observed clearances in Circuit#2 were slightly higher than clinical averages, likely due to the smaller molecular weight of the recombinant solute (31 vs. 33\u2009kDa), reduced circulation volume, and the absence of \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    -MG-IgA dimer binding complexes. This validated model provides a robust and reliable platform for the standardized assessment and development of next-generation blood purification devices.\n                  <\/jats:p>","DOI":"10.1177\/03913988261474708","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:28:31Z","timestamp":1792042111000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    replication of relationship between \u03b1\n                    <sub>1<\/sub>\n                    -microglobulin reduction rate and albumin leakage in post-dilution hemodiafiltration"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9312-2239","authenticated-orcid":false,"given":"Maozhen","family":"Li","sequence":"first","affiliation":[{"name":"Graduate School of Science and Engineering, Faculty of Science and Engineering, Hosei University, Koganei, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Nipro Corporation, Settsu, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Nipro Corporation, Settsu, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sunohara","sequence":"additional","affiliation":[{"name":"Nipro Corporation, Settsu, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-8742","authenticated-orcid":false,"given":"Akihiro C.","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering, Faculty of Science and Engineering, Hosei University, Koganei, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01853-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13040252"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac154"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-023-00471-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-021-00370-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346364"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/nep.14125"},{"issue":"1","key":"e_1_3_2_9_2","first-page":"67","article-title":"Medium cut-off dialyzer improves reduction ratios of large middle molecules associated with vascular calcification","volume":"43","author":"Kim HJ","year":"2024","unstructured":"Kim HJ, Seong EY, Song SH. Medium cut-off dialyzer improves reduction ratios of large middle molecules associated with vascular calcification. Kidney Res Clin Pract 2024; 43(1): 67\u201376.","journal-title":"Kidney Res Clin Pract"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-023-00495-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-025-00604-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10020145"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000185"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13278"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-021-00326-y"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74528-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.14740\/wjnu438"},{"issue":"1","key":"e_1_3_2_18_2","first-page":"11","article-title":"Comparison of albumin loss, reduction rates, and volumes of replacement fluid in different online hemodiafiltration modalities","volume":"38","author":"Pedrini LA","year":"2015","unstructured":"Pedrini LA, Feliciani A, Bernardi S. Comparison of albumin loss, reduction rates, and volumes of replacement fluid in different online hemodiafiltration modalities. Int J Artif Organs 2015; 38(1): 11\u201318.","journal-title":"Int J Artif Organs"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)43919-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2512403"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988261474708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03913988261474708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03913988261474708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:48:40Z","timestamp":1792324120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03913988261474708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":19,"alternative-id":["10.1177\/03913988261474708"],"URL":"https:\/\/doi.org\/10.1177\/03913988261474708","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"value":"0391-3988","type":"print"},{"value":"1724-6040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"03913988261474708"}}