{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:50:24Z","timestamp":1791568224835,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Artif Organs"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this study, the efficacy and safety of HA60 hemoadsorption in pediatric sepsis\/septic shock and multiple organ dysfunction were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eight patients who underwent HA60 hemoperfusion were analyzed. In addition to standard sepsis treatment, all patients received a single 6-h session with the HA60 filter. Along with the vasoactive inotropic score (VIS), CRP, IL-6, PCT, ferritin, lactate, AST, ALT, LDH, and bilirubin levels were evaluated at 0, 24, 48, and 72 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median age was 44.5 months, and 62.5% of the patients were male; 75% had underlying heart disease, all patients received invasive mechanical ventilation and CRRT, and 62.5% required ECMO. Following HA60, a significant decrease in CRP was observed up to 72 h (from 224.7 to 113.4 mg\/dL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), together with significant reductions in IL-6, PCT, and ferritin; IL-6 decreased by 71.7%, PCT by 79.7, and ferritin by 70.6% (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Lactate levels decreased from 3.5 to 2.4 mmol\/L (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and significant reductions were detected in AST, ALT, and LDH levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). A decrease in VIS was observed between the pre-filter and 72 h (from 55 to 45;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.034), and no procedure-related adverse events or hemodynamic instability were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In our study, HA60 hemoadsorption was associated with reductions in inflammatory markers, improvements in organ function parameters, and a decrease in vasoactive inotropic scores in critically ill children with septic shock. These findings are preliminary; prospective controlled studies are needed to establish the efficacy and optimal use of HA60 in pediatric septic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03913988261491718","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:58:02Z","timestamp":1791431882000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of HA60 hemoperfusion on inflammatory markers and organ function in critically ill children with septic shock"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-4774","authenticated-orcid":false,"given":"Serhat","family":"Emeksiz","sequence":"first","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furkan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Oglakcioglu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayd\u0131n","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadik","family":"Kaya","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Kockuzu Direk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001222"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1696366"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01326"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05878-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05220-7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9070768"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8120539"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1708479"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0391398820902469"},{"key":"e_1_3_4_11_2","unstructured":"Jafron. 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