{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:59:03Z","timestamp":1783479543060,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Onabotulinumtoxin-A has been approved for wet overactive bladder refractory to anticholinergics in randomised controlled trials; however, data from real-life practice are scarce. This study was designed to assess the efficacy of intravesical onabotulinumtoxin-A injections, focusing on health status, urinary symptoms and subjective satisfaction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Data from consecutive patients with overactive bladder-refractory to anticholinergics treated with onabotulinumtoxin-A were prospectively collected and analysed. Standard doses (100\u2013150 U) were used, followed by repeat sessions when clinical benefits diminished. Efficacy and safety of repeat onabotulinumtoxin-A administrations were assessed at 12-week post-injection. Clinical parameters evaluated were: change in the magnitude and frequency of incontinence, urgency and nocturia episodes, change in the number of pads used and procedural complications. Quality of life was evaluated using the 36-Item Short-Form Health Survey, Overactive Bladder Screener and Treatment Benefit Scale questionnaires. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Consecutive overactive bladder-refractory to anticholinergics patients ( n\u2009=\u200922) (median duration of oral therapy: 10\u2009months) were enrolled. No intraoperative complications occurred, but two urinary retention cases were recorded. Forty-five percent of patients (10\/22) were re-treated (median duration of perceived benefits: 18\u2009months, range: 8\u201355\u2009months). The number of urinary incontinence, frequency and nocturia episodes, and pads used went from 3.6, 11.3, 2.7 and 2.4 preoperatively to 1.0, 5.8, 0.7 and 0.7 postoperatively ( p\u2009&lt;\u20090.005). Quality of life (36-Item Short-Form Health Survey) was significantly improved and symptom scores (Overactive Bladder Screener) were reduced, from 34.5 to 17.1 at week\u200912 ( p\u2009&lt;\u20090.05). Eighty-seven percent of patients indicated improvement\/great improvement in their condition (Treatment Benefit Scale). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Intradetrusor injections of onabotulinumtoxin-A in patients with overactive bladder-refractory to anticholinergics significantly improved health status and urinary symptoms, with high subjective satisfaction. <\/jats:p><\/jats:sec>","DOI":"10.1177\/0391560318759258","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T17:56:55Z","timestamp":1527875815000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Onabotulinumtoxin-A improves health status and urinary symptoms in subjects with refractory overactive bladder: Real-life experience"],"prefix":"10.1177","volume":"85","author":[{"given":"Fabiola R","family":"Tamburro","sequence":"first","affiliation":[{"name":"Department of Urology, ASL02 Abruzzo, \u2018S.Pio da Pietrelcina\u2019 Hospital, Vasto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Castellan","sequence":"additional","affiliation":[{"name":"Department of Urology, ASL02 Abruzzo, \u2018S.Pio da Pietrelcina\u2019 Hospital, Vasto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Urology, ASL02 Abruzzo, \u2018S.Pio da Pietrelcina\u2019 Hospital, Vasto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Berardinelli","sequence":"additional","affiliation":[{"name":"Department of Urology, ASL02 Abruzzo, \u2018S.Pio da Pietrelcina\u2019 Hospital, Vasto, 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