{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:22:41Z","timestamp":1769307761934,"version":"3.49.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the efficacy of antioxidants in cellular-level post-ischemia\/reperfusion injury of the testis and to validate these effects with <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose positron emission tomography. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Fifty-six adult male rats were randomly divided into seven groups\u2014Group 1: sham; Group 2: ischemia\/reperfusion only group; Group 3: ischemia was induced and vitamin E (100\u2009mg\/kg) was administered intraperitoneally 30\u2009min before reperfusion; Group 4: vitamin E was given intraperitoneally without ischemia\/reperfusion; Group 5: ischemia was induced and coenzyme Q10 (10\u2009mg\/body weight) was administered intraperitoneally 30\u2009min before reperfusion; Group 6: coenzyme Q10 was administered intraperitoneally without ischemia\/reperfusion; Group 7: ischemia was induced and coenzyme Q10\u2009+\u2009vitamin E was administered intraperitoneally 30\u2009min before reperfusion. After detorsion, fluorodeoxyglucose was applied to all groups according to the animals\u2019 weight and fluorodeoxyglucose positron emission tomography was performed after 1\u2009h. In pursuit of imaging, orchiectomy was performed for histopathological and biochemical evaluations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A significant effect of group on catalase, maximum standardized uptake value, and seminiferous tubule diameters (p\u2009&lt;\u20090.005) was observed. According to this, combining ischemia\/reperfusion with vitamin E increased the maximum standardized uptake value significantly higher than in all other groups; in addition, catalase was significantly higher than in Groups 4\u20136. Histopathological outcomes revealed that \u201csham\u201d had significantly larger seminiferous tubule diameter than Groups 2\u20134. Also, \u201cischemia\/reperfusion\u201d was the only group which had significantly smaller seminiferous tubule diameters than Groups 6 and 7. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In contrast to vitamin E, coenzyme Q10 provided remarkable regression of oxidative stress\u2013induced enzymes and revealed consistent effects on histopathological outcomes, which were validated with fluorodeoxyglucose positron emission tomography imaging. <\/jats:p><\/jats:sec>","DOI":"10.1177\/0391560319882232","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T18:43:15Z","timestamp":1571251395000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Contrary effects of coenzyme Q10 and vitamin E after testicular ischemia\/reperfusion in a rat model validated with glucose metabolism imaging"],"prefix":"10.1177","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-6561","authenticated-orcid":false,"given":"Ersan","family":"Arda","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkan","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Akdere","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Department of Medical Education, School of Medicine, Marmara University, Istanbul, 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