{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:56:11Z","timestamp":1740808571203,"version":"3.38.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To evaluate the role of the microbiological profile and of disease-related factors in the management of patients affected with Fournier\u2019s gangrene (FG). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods:<\/jats:title><jats:p> Data regarding patients admitted for FG at nine Italian Hospitals (March 2007\u2013June 2018) were collected. Patients were stratified according to the number of microorganisms documented: Group A \u2013 one microorganism; Group B \u2013 two microorganisms; Group C \u2013 more than three microorganisms. Baseline blood tests, dedicated scoring systems, predisposing risk factors, disease\u2019s features, management and post-operative course were analyzed. UpSet technique for visualizing set intersections in a matrix layout and Cuzick\u2019s nonparametric test for trend across ordered groups were used. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Eighty-one patients were available for the analysis: 18 included in Group A, 32 in Group B, 31 in Group C. The most common microorganism isolated was Escherichia coli. In Group B-C, Escherichia coli was often associated to Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Statistically significant positive association was highlighted among the number of pathogens (Group A vs B vs C) and serum C-reactive Protein ( p &lt; 0.001), procalcitonin ( p = 0.02) and creatinine ( p = 0.03). Scoring systems were associated with the number of microorganisms detected ( p &lt; 0.02). A significant association between the number of microorganisms and the use of VAC therapy and need of a fecal diversion was found ( p &lt; 0.02). The number of microorganisms was positively associated with the length of stay (LOS) ( p = 0.02). Ten weeks after initial debridement, wound closure was achieved in 11 (91.7%), 22 (84.6%) and 20 (80%) patients in Group A, B, and C, respectively, with no differences in overall survival. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Polymicrobial infections in FG are positively associated with inflammatory scores, the need for fecal diversion and the LOS. This results may help the counseling and the clinical management of this rare niche of patients. <\/jats:p><\/jats:sec>","DOI":"10.1177\/03915603211018441","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T07:33:38Z","timestamp":1621668818000},"page":"437-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The microbiological profile of patients with Fournier\u2019s gangrene: A retrospective multi-institutional cohort study"],"prefix":"10.1177","volume":"89","author":[{"given":"Chiara","family":"Cipriani","sequence":"first","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital - GVM Care and Research, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-3177","authenticated-orcid":false,"given":"Valerio","family":"Iacovelli","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo 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