{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:33:35Z","timestamp":1737783215645,"version":"3.33.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Purpose:<\/jats:title><jats:p> To evaluate if the density of interstitial cells of Cajal (ICC) in the ureteropelvic junction (UPJ) influences the outcomes of pyeloplasty in adults. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Twenty-three patients with the diagnosis of ureteropelvic junction obstruction (UPJO) that underwent laparoscopic dismembered pyeloplasty were included. ICC density was measured using immunohistochemistry reaction for c-KIT expression in the resected UPJ segment. Pyeloplasty outcome was evaluated by patient self-report pain, urinary outflow using DTPA renogram and hydronephrosis assessment using ultrasound (US) at 12\u2009months of follow-up. A logistic regression analysis was performed to assess the association of pyeloplasty outcomes and ICC density. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Low, moderate, and high ICC density were present in 17.4%, 30.4%, and 52.2% of the patients, respectively. Complete pain resolution was observed in 100%, 85.7%, and 75% of patients with low, moderate and high ICC density, respectively ( p\u2009=\u20090.791). DTPA renogram improved in 75%, 85.7%, and 91.7% of patients with low, moderate and high ICC density, respectively ( p\u2009=\u20090.739). Hydronephrosis improved in 25%, 85.7%, and 91.7% of patients with low, moderate and high ICC density, respectively ( p\u2009=\u20090.032). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Patients with high ICC density have a significant amelioration of hydronephrosis after pyeloplasty. However, ICC density is not associated with functional outcomes. <\/jats:p><\/jats:sec>","DOI":"10.1177\/03915603221107470","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T06:34:37Z","timestamp":1656484477000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The influence of interstitial cells of Cajal density in the outcomes of pyeloplasty in adults: A prospective analysis"],"prefix":"10.1177","volume":"90","author":[{"given":"Victor","family":"Srougi","sequence":"first","affiliation":[{"name":"Division of Urology, University of Sao Paulo Medical School, Sao Paulo, Brazil"},{"name":"Hospital Moriah, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Anisio Santana de Torres","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Division of Urology, University of Sao Paulo Medical School, Sao Paulo, 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