{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:14:07Z","timestamp":1771528447163,"version":"3.50.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Vitamin D\u2019s role is noticeable on homeostasis of calcium and phosphorous and bone mineralization. Some studies prove that vitamin D has a role in reproductive pathways in male and females and its direct relationship with serum androgen levels in males. The common problem of infertility can be seen in 10%\u221215% of couples. 25%\u221250% of all infertilities is due to a male factor, and fertility disturbances are common in male CKD patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> This study aimed to figure out the effect of serum vitamin D levels on semen analysis parameters and reproductive hormones before and after renal transplantation in ESRD patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This double-blind randomized clinical trial was carried out on 70 ESRD males (21\u201348 years old) who were candidates for renal transplantation at Sina hospital between 2021 and 2022. Participants were divided into two groups randomly. First group was supplemented by vitamin D (50,000 units weakly until 3 months), and no intervention was done in the second group. Vitamin D levels, LH, FSH, creatinine, glomerular filtration rate (GFR), calcium, total and free testosterone, PTH, sexual function, and semen analysis parameters were evaluated in a determined interval before and after (three and 6 months) kidney transplantation <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Vitamin D levels were noticeably higher in case group in comparison to the control group ( p-value &lt; 0.01) but the difference in all other variables including calcium levels, LH, FSH, total and free testosterone, IIEF-5 score, PTH, GFR, and creatinine was insignificant ( p-value &gt; 0.05). The comparison of semen parameters of the case with control group including sperm count, morphology, volume, and motility didn\u2019t reveal a noticeable difference between the two groups ( p-value &gt; 0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Prescription of vitamin D as a supplementation doesn\u2019t improve sperm quality (sperm count, motility, morphology, and volume) and reproductive hormones (LH, FSH, free and total testosterone) after kidney transplantation in male CKD patients. <\/jats:p><\/jats:sec>","DOI":"10.1177\/03915603231162394","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T07:15:44Z","timestamp":1680506144000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the relationship between vitamin D with semen analysis parameters and reproductive hormones levels before and after kidney transplantation: An Iranian randomized and double-blinded study"],"prefix":"10.1177","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-3664","authenticated-orcid":false,"given":"Hossein","family":"Dialameh","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Nikoobakht","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Menbari Oskouie","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazanin","family":"Rahimdoost","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-4884","authenticated-orcid":false,"given":"Mohammad Javad","family":"Nazarpour","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hamid","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shima","family":"Esmaeilpanah","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Inanloo","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"bibr1-03915603231162394","unstructured":"United States Renal Data System. 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