{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T03:02:35Z","timestamp":1763348555381,"version":"3.38.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> We aimed to identify clinical and radiological predictors of the need for surgical intervention in infants with antenatally detected UPJO. <\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods:<\/jats:title><jats:p> We prospectively followed infants born with antenatally diagnosed ureteropelvic junction obstruction (UPJO) presented at our outpatient clinics for evidence of obstructive injury with a standard protocol with ultrasonography and renal scintigraphy. Indications for surgery included progression of hydronephrosis on serial examinations, initial differential renal function (DFR) \u2a7d35% or &gt;5% loss in sequential studies, and febrile urinary tract infection (UTI). Univariate and multivariate analyses were utilized to define the predictors for surgical intervention, while the appropriate cut-off value of the initial Anteroposterior diameter (APD) was determined using the receiver operator curve analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Univariate analysis revealed a significant association between surgery, the initial APD, cortical thickness, Society for Fetal Urology grade, UTD risk group, initial DRF, and febrile UTI ( p-value\u2009&lt;\u20090.05). No significant association between surgery and sex or side of the affected kidney ( p-value 0.91 and 0.38, respectively). On multivariate analysis, the initial APD, initial DRF, obstructed renographic curve, and febrile UTI ( p-value\u2009&lt;\u20090.05) were the only independent predictors for surgical intervention. An initial APD of 23\u2009mm can predict surgical requirement, with a specificity of 95% and sensitivity of 70%. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> For antenatally diagnosed UPJO, the APD value (at the age of 1\u2009week), DFR value (at the age of 6\u20138\u2009weeks), and febrile UTI during follow-up are significant and independent predictors of the need for surgical intervention. APD, when used with a cut-off value of 23\u2009mm, is associated with high specificity and sensitivity for predicting surgical need. <\/jats:p><\/jats:sec>","DOI":"10.1177\/03915603231173009","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T11:06:00Z","timestamp":1685099160000},"page":"220-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of surgical intervention for antenatally detected ureteropelvic junction obstruction (UPJO): A prospective multivariate analysis"],"prefix":"10.1177","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-0036","authenticated-orcid":false,"given":"Tarek Ahmed","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Faculty of medicine, Sohag university, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam El din Salem","family":"Morsy","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Sohag university, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany Abd Elraoof Ali","family":"Morsy","sequence":"additional","affiliation":[{"name":"Kasr Al Ainy Faculty of medicine, Cairo university, Al Manial, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelmoneim Mohammed","family":"Abouzeid","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Sohag university, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem Mohamed","family":"Elmoghazy","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Sohag university, Sohag, 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