{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:23:43Z","timestamp":1787235823655,"version":"build-2736575974"},"reference-count":9,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Chronic radiation cystitis (CRC) develops after radiation therapy and can present with symptoms like urinary frequency, urgency, pelvic pain, and nocturia. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory CRC patients for up to 3\u2009months. Herein, we evaluated the durability of ABT up to 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>CRC patients recalcitrant to previous treatments received ABT comprised of intra-detrusor injections of 100\u2009mg micronized AM diluted in 10\u2009mL 0.9% preservative-free sodium chloride. Clinical evaluation and questionnaires (Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain\/Interstitial Cystitis Symptom Score (BPIC-SS), Overactive Bladder (OAB) Assessment Tool, SF-12 Health Survey) were repeated at pre-op and 2, 4, 8, 12, 16, 20, 24, and 36\u2009weeks post-injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five consecutive patients with a mean age of 64.4\u2009\u00b1\u200920.1\u2009years with a median CRC duration of 10\u2009years were included and followed for 6\u2009months. After ABT, the lower urinary tract symptoms improved as early as 2\u2009weeks and were maintained up to 20\u2009weeks. BPIC significantly improved from 36.6\u2009\u00b1\u20091.1 at baseline to 12.6\u2009\u00b1\u20091.5 at 16\u2009weeks and 13.8\u2009\u00b1\u20092.9 at 20\u2009weeks. At 24 and 36\u2009weeks, the improvement was maintained in four (80%) of the five patients (BPIC\u2009=\u200913.8\u2009\u00b1\u20091.0). Uroflow assessment showed voiding volume improved two-fold in four of the five patients at 24\u2009weeks compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our data suggest that a significant number of CRC patients may have durable benefit after ABT. Despite this, some of them can show symptoms rebound at 24\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603241248014","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T06:02:20Z","timestamp":1713765740000},"page":"623-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of chronic post-radiation cystitis with trans-urethral amniotic bladder therapy appears durable at 9\u2009months: A clinical study"],"prefix":"10.1177","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8344-6371","authenticated-orcid":false,"given":"Jonathan","family":"Lutchka","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Vercnocke","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fisher","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codrut","family":"Radoiu","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Jeberaeel","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lucas","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"},{"name":"John D. Dingell VA Medical Center, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivedita","family":"Dhar","sequence":"additional","affiliation":[{"name":"John D. Dingell VA Medical Center, Detroit, MI, USA"},{"name":"Detroit Medical Center, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"bibr1-03915603241248014","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14516"},{"key":"bibr2-03915603241248014","doi-asserted-by":"publisher","DOI":"10.3390\/biology11070972"},{"key":"bibr3-03915603241248014","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17637"},{"key":"bibr4-03915603241248014","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.tjo_4_20"},{"key":"bibr5-03915603241248014","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup2.S4"},{"key":"bibr6-03915603241248014","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03652-8"},{"key":"bibr7-03915603241248014","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.06.032"},{"key":"bibr8-03915603241248014","first-page":"11607","volume":"30","author":"Radoiu C","year":"2023","journal-title":"Can J Urol"},{"key":"bibr9-03915603241248014","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.02.043"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603241248014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03915603241248014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603241248014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:45:03Z","timestamp":1741005903000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03915603241248014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1177\/03915603241248014"],"URL":"https:\/\/doi.org\/10.1177\/03915603241248014","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"value":"0391-5603","type":"print"},{"value":"1724-6075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]}}}