{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T06:11:28Z","timestamp":1740809488798,"version":"3.38.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> to investigate the association between anogenital distance (AGD) and the risk of Late-onset Hypogonadism (LOH). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We prospectively recruited 145 consecutive patients referred for transrectal prostate biopsy due to prostate-specific antigen (PSA) elevation or abnormal digital rectal examination, between September 2019 and December 2021. Two variants of AGD, anus to scrotum base (AGDas) and anus to dorsal insertion of penis (AGDap) were measured. Serum total testosterone levels in fasting conditions between 07.00 and 11.00\u2009h were determined. Patients filled out the Aging Males\u2019 Symptoms (AMS) scale questionnaire. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> LOH was diagnosed in 29% of the participants and presented both AGDs shorter than men without LOH, with an AGDap of 116.09\u2009mm (9.02\u2009mm) versus 128.71 (10.76), and an AGDas 29.70 (8.01) versus 39.93 (11.64); both p\u2009&lt;\u20090.05. ANCOVA test showed a significant association between the presence of LOH and both AGD measurements. Besides, AGD measurements presented adequate accuracy for the diagnosis of LOH. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> This work adds to the scientific evidence that AGD\u2014a biomarker of fetal exposure\u2014could provide a non-invasive measure to address LOH, providing a potential useful clinical tool. <\/jats:p><\/jats:sec>","DOI":"10.1177\/03915603241287881","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:39:01Z","timestamp":1727685541000},"page":"134-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anogenital distance and the risk of Late-onset hypogonadism"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-2525","authenticated-orcid":false,"given":"Florencio Manuel","family":"Mar\u00edn-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Attending, Department of Urology, Santa Luc\u00eda General University Hospital, Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian J","family":"Arense-Gonzalo","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine of the University of Murcia, Espinardo (Murcia), Spain"},{"name":"Biomedical Research Institute of Murcia, IMIB-Arrixaca, El Palmar (Murcia), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Artes","family":"Artes","sequence":"additional","affiliation":[{"name":"Attending, Department of Urology, Santa Luc\u00eda General University Hospital, Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emny Rochell","family":"Bobadilla Romero","sequence":"additional","affiliation":[{"name":"Attending, Department of Urology, Santa Luc\u00eda General University Hospital, Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-2937","authenticated-orcid":false,"given":"Victor","family":"Garcia Porcel","sequence":"additional","affiliation":[{"name":"Urology Resident, Reina Sof\u00eda General University Hospital, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel Coromoto","family":"Su\u00e1rez-Pineda","sequence":"additional","affiliation":[{"name":"Attending, Emergency Department, General Hospital de la Vega Lorenzo Guirao of Cieza, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Luis","family":"Guzm\u00e1n Mart\u00ednez-Valls","sequence":"additional","affiliation":[{"name":"Head of Urology Department, General Hospital Virgen de la Arrixaca of Murcia, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Mendiola","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine of the University of Murcia, Espinardo (Murcia), Spain"},{"name":"Biomedical Research Institute of Murcia, IMIB-Arrixaca, El Palmar (Murcia), Spain"},{"name":"Biomedical Research Consortium in Epidemiology and Public Health (CIBER Epidemiology and Public Health, CIBERESP), Carlos III Health Institute, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"bibr1-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12156"},{"key":"bibr2-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1100"},{"key":"bibr3-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00019.x"},{"key":"bibr4-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2370"},{"key":"bibr5-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205221"},{"key":"bibr6-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22845"},{"key":"bibr7-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12022"},{"key":"bibr8-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.041"},{"key":"bibr9-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018973"},{"key":"bibr10-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1103421"},{"key":"bibr11-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03511-6"},{"key":"bibr12-03915603241287881","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2017.68595"},{"key":"bibr13-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911101"},{"key":"bibr14-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-15"},{"key":"bibr15-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)34871-1"},{"key":"bibr16-03915603241287881","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031719"},{"key":"bibr17-03915603241287881","unstructured":"Capogrosso 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