{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:07:33Z","timestamp":1791198453573,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>Aim:<\/jats:title>\n            <jats:p>To evaluate the role of preoperative neutrophils to lymphocytes ratio (NLR) as a predictor for the response to BCG in patients with non-muscle invasive bladder cancer (NMIBC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials:<\/jats:title>\n            <jats:p>Nighty six patients with NMIBC were prospectively included in our study. Our study population was classified into two groups, based on pre-operative (NLR) either\u2009\u2a7d\u2009or\u2009&gt;\u20093. After receiving BCG, patients were followed up for 3\u2009years to evaluate the correlation between BCG failure and (NLR).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Nighty two patients were evaluated at the end of our study. The NLR\u2009&gt;\u20093 group of patients showed a higher age and T stage compared to the NLR\u2009\u2a7d\u20093 group with a significant difference. BCG failure was reported to be higher in the NLR\u2009&gt;\u20093 group with a failure rate of 66.7% compared to 28.3% in the other group (\n              <jats:italic>p<\/jats:italic>\n              -value\u2009&lt;\u20090.001). Time to failure in NLR\u2009&gt;\u20093 group compared to NLR\u2009\u2a7d\u20093 group was 10.44\u2009\u00b1\u20094.3 and 15\u2009\u00b1\u20093.9\u2009months respectively with a (\n              <jats:italic>p<\/jats:italic>\n              -value\u2009=\u20090.002). Univariate and multivariate logistic regression revealed that the most significant predictors of BCG failure were NLR\u2009&gt;\u20093, Initial T stage, and age respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>BCG response is highly affected by the NLR, with a higher failure rate with NLR\u2009&gt;\u20093.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1177\/03915603241308974","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T06:05:26Z","timestamp":1735970726000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neutrophils to lymphocytes ratio as a predictor of BCG response in non-muscle invasive bladder cancer"],"prefix":"10.1177","volume":"92","author":[{"given":"Ahmed","family":"Higazy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Elsawy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Lofty","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany M","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-4241","authenticated-orcid":false,"given":"Ahmed","family":"Radwan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.11.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Babjuk M Burger M Capoun O Cohen D Comp\u00e9rat EM Dominguez Escrig JL et al. European association of urology guidelines on non\u2013muscle-invasive bladder cancer (Ta T1 and Carcinoma in Situ). Eur Urol [Internet] 2022; 81(1): 75\u201394. 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Blood count-derived inflammatory markers predict time to Bacillus Calmette-Gu\u00e9rin failure in high-risk non-muscle-invasive bladder cancer. Arch Med Sci 2021; 17: 1\u20139.","journal-title":"Arch Med Sci"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59038-3_17"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110393"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/03915603211035191"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528740"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16486"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00642"},{"issue":"2","key":"e_1_3_2_21_2","article-title":"Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non \u2013 muscle-invasive bladder cancer","volume":"33","author":"Mano R","year":"2015","unstructured":"Mano R, Baniel J, Shoshany O, et al. Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non \u2013 muscle-invasive bladder cancer. Urol Oncol Semin Orig Investig 2015; 33(2): 67.e1\u201367.e7.","journal-title":"Urol Oncol Semin Orig Investig"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0404-x"},{"issue":"1","key":"e_1_3_2_23_2","first-page":"3628384","article-title":"Comparison of preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios in bladder cancer patients undergoing radical cystectomy","volume":"2019","author":"Wang R","year":"2019","unstructured":"Wang R, Yan Y, Liu S, et al. Comparison of preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios in bladder cancer patients undergoing radical cystectomy. 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