{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:18:45Z","timestamp":1786598325738,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    The purpose of this study is that the combination effects of Peyronie\u2019s disease (PD) therapy with Phosphodiesterase type 5 inhibitors (PDE5i) plus acetylsalicylic acid on improve curvature progression and pain in the active phase of disease. We performed a retrospective cohort study of 161 patients affected by PD in active stage and erectile dysfunction treated with tadalafil 5\u2009mg once daily were divided in two groups. Group A(GA): 93 men treated with only PDE5i (tadalafil 5\u2009mg) for 1\u2009year or more and Group B(GB): 68 men that received tadalafil 5\u2009mg plus aspirin 100\u2009mg with the same protocol of GA. The patients of both groups were assessed at baseline and follow-up (6\u2009months) for erectile function, painful erections, penile plaque size, and penile curvature. Six months after the treatment the patients in both groups had a non-significantly reduction of penile plaques. However, in GB patients had a clinically significant reduction of the curvature after 6\u2009months by treatments 20.21\u00b0\u2009\u00b1\u20097.20 versus 28.13\u00b0\u2009\u00b1\u20098.11 (GA), (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In the analysis of our secondary endpoint, we demonstrated a significantly lower intensity of pain during erection in GB (1.43\u2009\u00b1\u20091.12) compared GA (1.89\u2009\u00b1\u20091.25;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). We observed that the regular use of this therapeutic combination significantly provided more benefit in patients with active stage PD in terms of penile deformity, pain, and discomfort during penetrative intercourses.\n                  <\/jats:p>","DOI":"10.1177\/03915603251344448","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T02:49:34Z","timestamp":1748141374000},"page":"728-733","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Daily phosphodiesterase type 5 inhibitors plus acetylsalicylic acid improve curvature progression and pain intensity during the active phase of peyronie\u2019s disease"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-9965","authenticated-orcid":false,"given":"Lucio","family":"Dell\u2019Atti","sequence":"first","affiliation":[{"name":"Department of Urology, University-Hospital of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Slyusar","sequence":"additional","affiliation":[{"name":"Pain Therapy Center, Division of Anesthesia and intensive Care, University-Hospital of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2019.06.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14230"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2021.07.013"},{"issue":"7","key":"e_1_3_3_5_2","article-title":"Non-surgical therapies for peyronie\u2019s disease","volume":"7","author":"Rosenberg JE","year":"2023","unstructured":"Rosenberg JE, Ergun O, Hwang EC, et al. Non-surgical therapies for peyronie\u2019s disease. Cochrane Database Syst Rev 2023; 7(7): CD012206.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_50_19;"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.152048"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07223.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(17)30442-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14520"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1700\/1660.18156"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae324"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.04.010"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2023.2288347"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2003.12.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02217.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-013-1036-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-022-00651-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2022.3.319"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318337"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1329847"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.12187"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)01000-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44386-x"},{"key":"e_1_3_3_25_2","article-title":"Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction: a systematic review","volume":"97","author":"Li T","year":"2018","unstructured":"Li T, Wu C, Fu F, et al. Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction: a systematic review. Med 2018; 97: e11367.","journal-title":"Med"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.061"},{"key":"e_1_3_3_27_2","first-page":"11","article-title":"Peyronie\u2019s disease: what do we know and how do we treat it?","volume":"27","author":"Chung PH","year":"2020","unstructured":"Chung PH, Han TM, Rudnik B, et al. Peyronie\u2019s disease: what do we know and how do we treat it? 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