{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:29:13Z","timestamp":1784694553035,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The most prevalent cancer in men is prostate cancer (PCa). One significant discovery involves attacking tumors with mutations in DNA damage repair genes via the blockage of poly(ADP-ribose) polymerase (PARP) enzymes. In this study, we provide a summary of the present research status of PARP inhibitors in PCa, highlighting areas of interest and emerging trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Our search covered the Scopus database for literature on PARP inhibitors in PCa up to the year 2023. We conducted a scientometric review using VOSviewer to evaluate the output across countries, institutions, authors, journals, references, and keywords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 1850 articles on PARP inhibitors in prostate cancer (PCa) published until 2023, with medicine, biochemistry, and pharmacology being the most represented subject areas. The United States led in publication volume (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009800, 43.2%), followed by the United Kingdom (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009281, 15.2%) and China (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009198, 10.7%), and also achieved the highest total citations and H-index. A positive correlation was identified between publication volume and gross domestic product (GDP;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.843,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                      <jats:italic toggle=\"yes\">Antonarakis, E.S.<\/jats:italic>\n                      , from the United States, ranked as the most prolific author (49 publications) and achieved the highest H-index, while Mateo, J. was the most cited. The\n                      <jats:italic toggle=\"yes\">Institute of Cancer Research<\/jats:italic>\n                      emerged as the most active institution, publishing 91 articles, and the journal\n                      <jats:italic toggle=\"yes\">Cancers<\/jats:italic>\n                      contributed the highest number with 99 articles. In keyword analysis, \u201cprostate cancer\u201d and \u201cPARP inhibitors\u201d were the most used terms, forming six thematic clusters. Citation and co-citation analysis highlighted the influential role of high-impact journals like\n                      <jats:italic toggle=\"yes\">New England Journal of Medicine<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Journal of Clinical Oncology<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The United States has taken the lead in this sector by making the largest contribution in terms of overall publications. Although international partnerships are occurring globally, there is a need for more assistance and expansion of research on PAPR inhibitors in PCa, particularly in underdeveloped nations. This study offers assistance to medical professionals, scientists, and surgery assistants on the worldwide results of PAPR inhibitors in PCa research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603251360527","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:51:58Z","timestamp":1754477518000},"page":"630-642","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Advances in targeted therapies by PARP inhibitors for the treatment of prostate cancer: A scientometric approach"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2983-0485","authenticated-orcid":false,"given":"Iman","family":"Menbari Oskouie","sequence":"first","affiliation":[{"name":"Urology Research Center, Tehran University of Medical Sciences, Tehran, 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