{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:55:39Z","timestamp":1791237339197,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in aging men, significantly impacting quality of life. Although pharmacological therapies, especially alpha-blockers, are the standard first-line treatment, their long-term adherence is limited by side effects and insufficient symptom control. Transurethral resection of the prostate (TURP) remains the surgical gold standard but is associated with notable morbidity, prompting interest in minimally invasive alternatives. The temporary implantable nitinol device (I-Tind) offers a tissue-sparing approach designed to remodel the prostatic urethra and relieve LUTS without compromising sexual function. This multicenter prospective study evaluated the safety, efficacy, and functional outcomes of I-Tind in 120 patients with symptomatic BPH unresponsive to alpha-blockers, treated between 2019 and 2023. Follow-up assessments were done at 3, 6, and 12\u2009months. The study showed significant improvements in urinary flow and symptom scores. Mean Qmax improved from 7.6 to 15.7\u2009mL\/s, and mean IPSS decreased from 21.5 to 9.7 at 12\u2009month-follow-up (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Quality of life measures also improved, and sexual and ejaculatory functions were fully preserved. The procedure was well-tolerated, with all implants successfully retrieved after a mean of 6\u2009days and a low complication rate. I-Tind appears to be a safe and effective minimally invasive option for selected BPH patients, combining symptom relief with preservation of quality of life. Further randomized trials are needed to confirm these findings and better define its role in the BPH treatment algorithm.\n                  <\/jats:p>","DOI":"10.1177\/03915603251360530","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T14:06:51Z","timestamp":1754316411000},"page":"693-697","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["I-Tind for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Mid-term outcomes from a multicenter cohort"],"prefix":"10.1177","volume":"92","author":[{"given":"Mauro","family":"Dimitri","sequence":"first","affiliation":[{"name":"School of Urology, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Calarco","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Filippi","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Viscuso","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Asero","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-4523","authenticated-orcid":false,"given":"Guglielmo","family":"Mantica","sequence":"additional","affiliation":[{"name":"Department of Urology Policlinico San Martino Hospital, University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2160-763X","authenticated-orcid":false,"given":"Francesca","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Department of Urology Policlinico San Martino Hospital, University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Spena","sequence":"additional","affiliation":[{"name":"Department of Urology, Istituto Nazionale Tumori, IRCCS, \u201cFondazione G. Pascale,\u201d Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bucca","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Schiavina","sequence":"additional","affiliation":[{"name":"Division of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Piazza","sequence":"additional","affiliation":[{"name":"Division of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Iacono","sequence":"additional","affiliation":[{"name":"Musumeci GECAS Clinic, Gravina di Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-2216","authenticated-orcid":false,"given":"Antonio","family":"Tufano","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, Roma, Italy"},{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Musumeci GECAS Clinic, Gravina di Catania, Italy"},{"name":"Medicine and Surgery University KORE of Enna \u2013 Operative Unit of Urology, Musumeci GECAS Clinic, Gravina of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00354-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2024.13098"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00376-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2023.2237406"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-3232-x"},{"issue":"5","key":"e_1_3_2_7_2","first-page":"446","article-title":"From \u201cgold standard\u201d resection to reproducible \u201cfuture standard\u201d endoscopic enucleation of the prostate: what we know about anatomical enucleation","volume":"69","author":"Naspro R","year":"2017","unstructured":"Naspro R, Gomez Sancha F, Manica M, et al. From \u201cgold standard\u201d resection to reproducible \u201cfuture standard\u201d endoscopic enucleation of the prostate: what we know about anatomical enucleation. Minerva Urol Nefrol 2017; 69(5): 446\u2013458.","journal-title":"Minerva Urol Nefrol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.005"},{"issue":"4","key":"e_1_3_2_9_2","first-page":"12003","article-title":"New minimally invasive solutions for Benign Prostatic Obstruction (BPO) management: a position paper from the UrOP (Urologi Ospedalit\u00e0 Gestione Privata)","volume":"95","author":"Leonardi R","year":"2023","unstructured":"Leonardi R, Ambrosini F, Malinaric R, et al. New minimally invasive solutions for Benign Prostatic Obstruction (BPO) management: a position paper from the UrOP (Urologi Ospedalit\u00e0 Gestione Privata). 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