{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:05:36Z","timestamp":1774346736977,"version":"3.50.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effect of neoadjuvant chemotherapy (NAC) on short-term complications following robotic radical cystectomy (RRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective review of 134 bladder cancer patients who underwent RRC. Perioperative outcomes were compared between patients who received NAC (nRRC) and those who underwent upfront RRC (uRRC). Primary outcome: 30-day Clavien-Dindo classification score of \u2a7e2 (CDC\u2009\u2a7e\u20092). Secondary outcomes: 30-day infectious complications, readmission rates, postoperative ileus, blood transfusion, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 134 patients, 90 (67%) were in the nRRC group and 44 (33%) in the uRRC group. The total 30-day CDC\u2009\u2a7e\u20092 complication rates and high-grade complications were comparable between the groups. Among the various outcomes assessed, only postoperative ileus showed a statistically significant difference, with lower rates in the nRRC (20% vs 38.4%, OR\u2009=\u20090.39,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.021). Other outcomes, including 30-day readmission, infectious complications and blood transfusions, were similar. All four cases of 30-day mortality occurred in the nRRC group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NAC in the era of RRC was not associated with a statistically significant increase in overall perioperative complication rates in our cohort. NAC can likely be administered without a significant increase in perioperative complications, although confirmation in larger studies is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603251360580","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T11:58:47Z","timestamp":1754740727000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of neoadjuvant chemotherapy on short-term complications following robotic radical cystectomy"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4986-3515","authenticated-orcid":false,"given":"Ameer","family":"Nsair","sequence":"first","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"},{"name":"Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-8987","authenticated-orcid":false,"given":"Kamil","family":"Malshy","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9769-4517","authenticated-orcid":false,"given":"Hussein","family":"Hijazi","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1968-7556","authenticated-orcid":false,"given":"Etan","family":"Eigner","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-5415","authenticated-orcid":false,"given":"Nicola","family":"Feza","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0826-0922","authenticated-orcid":false,"given":"Melissa","family":"Atallah","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-2935","authenticated-orcid":false,"given":"Azik","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"},{"name":"Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-4655","authenticated-orcid":false,"given":"Gilad E","family":"Amiel","sequence":"additional","affiliation":[{"name":"Department of Urology, Rambam Healthcare Campus, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.03.029"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.033"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16223766"},{"issue":"3","key":"e_1_3_2_5_2","first-page":"345","article-title":"Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data","volume":"84","author":"Advanced Bladder Cancer (ABC) Meta-analysis Collaboration","year":"2023","unstructured":"Advanced Bladder Cancer (ABC) Meta-analysis Collaboration. 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