{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:51:36Z","timestamp":1769680296473,"version":"3.49.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Compared to other overactive bladder (OAB) symptoms, incontinence has a more negative impact on quality of life and is frequently challenging to treat with antimuscarinic monotherapy. This study\u2019s goal was to compare the safety, tolerability, and effectiveness of a combination of solifenacin 5\u2009mg and mirabegron 25\u2009mg or 50\u2009mg versus solifenacin 5\u2009mg in patients with OAB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>In a tertiary care hospital, 258 individuals with overactive bladders participated in a randomised controlled open-label research to examine the safety and efficacy of mirabegron as a supplement to solifenacin. Randomisation was used to assign patients to one of three groups: those receiving solifenacin (5\u2009mg) with mirabegron (25\u2009mg), solifenacin (5\u2009mg) plus mirabegron (50\u2009mg) or solifenacin (5\u2009mg) monotherapy. OABSS was used to examine the patients. A change in the OABSS from baseline to end of treatment (EOT) was the main outcome measure. This research also examined the safety and tolerability of combination treatment in comparison to solifenacin monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All combinations with solifenacin five substantially improved the OAB symptoms score as compared to solifenacin 5\u2009mg monotherapy. When compared to solifenacin 5\u2009mg, both combination groups significantly decreased the frequency of micturition. Although there were no dose-related differences between the combination and monotherapy groups in terms of TEAEs, blood pressure, pulse rate, PVR volume, or laboratory or ECG parameters, combination medication did result in a slightly higher frequency of constipation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>When compared to solifenacin 5\u2009mg monotherapy, combination therapy with solifenacin\/mirabegron markedly improved OABSS, micturition frequency, and urgency. When compared to monotherapy, all combinations were well tolerated and showed no significant extra safety concerns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603251378596","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T10:26:50Z","timestamp":1758364010000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination treatment of mirabegron and solifenacin versus solifenacin monotherapy in female patients with overactive bladder \u2013 A comparative study on effectiveness, safety, symptoms and quality of life and treatment adherence"],"prefix":"10.1177","volume":"93","author":[{"given":"Rathindra Nath","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Post Graduate Medical Education and Research, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6879-6021","authenticated-orcid":false,"given":"Anshu","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Urology, Tata Main Hospital, Jamshedpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchita","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Jagannath Gupta Institute of Medical Sciencs and Hospital, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GS","family":"Kamilya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Post Graduate Medical Education and Research, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taquedis","family":"Noori","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Post Graduate Medical Education and Research, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Post Graduate Medical Education and Research, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.02.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.06.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.21276\/obgyn.2020.7.6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-0880-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.37"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-012-0167-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-021889"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12194"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0301-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00097-6"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1998)17:5<467::AID-NAU2>3.0.CO;2-B"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1244-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13068"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.047"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09036.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756287215589250"},{"issue":"4","key":"e_1_3_2_19_2","first-page":"641","article-title":"The role of alternative medicine and complimentary therapies in urologic disease: new horizons","volume":"91","author":"Bizzarri FP","year":"2024","unstructured":"Bizzarri FP, Campetella M, Ragonese M, et al. The role of alternative medicine and complimentary therapies in urologic disease: new horizons. 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