{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:10:32Z","timestamp":1775823032264,"version":"3.50.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Ureteropelvic junction obstruction (UPJO) is a major cause of obstructive uropathy in pediatric patients. However, the optimal management remains controversial. We aimed to summarize the evidence comparing surgical versus conservative treatment. We searched MEDLINE\/PubMed (2016 to 31 October 2024) and the Cochrane Central Register of Controlled Trials (CENTRAL) on 31 October 2024. The primary outcome was split renal function (SRF). Results were summarized in a structured table. Study quality was assessed using the ROBINS-I tool and the level of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. Our search resulted in 2.251 reports. We included two non-randomized interventional studies with 136 patients. One study reported no statistically significant difference in SRF between the study groups after 1\u2009year of follow up, while the second study reported higher SRF in surgical group 6\u2009months postoperatively. The studies were judged to have a serious risk of bias, and the quality of evidence was rated as very low. The paucity of eligible data precluded the performance of a meta-analysis. Our findings could not support clinical recommendations. This study highlights the lack of high-quality evidence that will come from large, prospective, well-designed trials comparing surgical intervention to updated conservative treatment options.<\/jats:p>","DOI":"10.1177\/03915603251384442","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:48:51Z","timestamp":1762778931000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of surgical versus conservative treatment in ureteropelvic junction obstruction: A systematic review of non-randomized trials"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7108-7663","authenticated-orcid":false,"given":"Despoina","family":"Samourkasidou","sequence":"first","affiliation":[{"name":"4th Department of Pediatrics, \u201cG.Papageorgiou\u201d General Hospital School of Medicine, Department of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-7384","authenticated-orcid":false,"given":"Despoina","family":"Tramma","sequence":"additional","affiliation":[{"name":"4th Department of Pediatrics, \u201cG.Papageorgiou\u201d General Hospital School of Medicine, Department of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8348-8520","authenticated-orcid":false,"given":"Nikolaos","family":"Gkiourtzis","sequence":"additional","affiliation":[{"name":"4th Department of Pediatrics, \u201cG.Papageorgiou\u201d General Hospital School of Medicine, Department of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-7929","authenticated-orcid":false,"given":"Vaia","family":"Dokousli","sequence":"additional","affiliation":[{"name":"4th Department of Pediatrics, \u201cG.Papageorgiou\u201d General Hospital School of Medicine, Department of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-0574","authenticated-orcid":false,"given":"Thomas","family":"Karagiannis","sequence":"additional","affiliation":[{"name":"Second Medical Department, \u201cHippokration\u201d General Hospital School of Medicine, Department of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Clinical Research and Evidence-Based Medicine Unit, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalis","family":"Aivaliotis","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece"},{"name":"Functional Proteomics and Systems Biology (FunPATh), Center for Interdisciplinary Research and Innovation (CIRI-AUTH), University Campus, Thessaloniki, Greece"},{"name":"Basic and Translational Research Unit, Special Unit for Biomedical Research and Education, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2020.01.01"},{"key":"e_1_3_2_3_2","article-title":"Surgery versus non-surgical management for unilateral ureteric-pelvic junction obstruction in newborns and infants less than two years of age","volume":"7","author":"Weitz M","year":"2016","unstructured":"Weitz M, Portz S, Laube GF, et al Surgery versus non-surgical management for unilateral ureteric-pelvic junction obstruction in newborns and infants less than two years of age. Cochrane Database Syst Rev 2016; 7: CD010716.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_4_2","volume-title":"EAU guidelines on paediatric urology","author":"Radmayr C","year":"2023","unstructured":"Radmayr C. EAU guidelines on paediatric urology. Arnhem, The Netherlands: EAU, 2023."},{"key":"e_1_3_2_5_2","volume-title":"Pediatric ureteropelvic junction obstruction treatment & management","author":"Meier K","year":"2024","unstructured":"Meier K. Pediatric ureteropelvic junction obstruction treatment & management. Medscape (WeMD). New York, NY: WebMD LLC, 2024."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3291-3"},{"key":"e_1_3_2_7_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. 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