{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:32:04Z","timestamp":1794353524507,"version":"4.9.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anterior urethral strictures significantly impact urinary function and quality of life, often requiring surgical intervention. This study evaluates the histopathological characteristics of strictures and their correlation with urethroplasty outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A prospective study was conducted on 65 male patients (aged 20\u201360) diagnosed with anterior urethral strictures at SMS Medical College. Exclusion criteria included posterior urethral distraction defects and prior surgical interventions. Biopsies from stricture sites were analyzed for lichen sclerosus (LS) and inflammation. Urethroplasty techniques included dorsal augmentation, ventral onlay buccal mucosal graft, Asopa\u2019s dorsal inlay, and staged urethroplasty. Statistical analysis was performed using the chi-square test, independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, and ANOVA, with a significance threshold of\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The majority of strictures were idiopathic (46.1%), followed by LS (26.1%) and iatrogenic causes (21.5%). LS was significantly associated with poorer surgical outcomes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.032). Severe inflammation within the stricture segment correlated with unsuccessful urethroplasty outcomes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027), whereas inflammation in proximal or distal segments showed no impact. Stricture length\u2009&gt;\u20098\u2009cm also exhibited higher failure rates. The most common postoperative complication was wound infection (13.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LS and severe inflammation are key predictors of unsuccessful urethroplasty outcomes. Histopathological evaluation should be integrated into preoperative assessment to optimize surgical planning and reduce recurrence rates. Future studies with larger cohorts and extended follow-ups are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603251388207","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:15:02Z","timestamp":1762928102000},"page":"265-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of anterior urethral strictures based on histopathology and its correlation with outcome after urethroplasty"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2037-2477","authenticated-orcid":false,"given":"Goyal","family":"Prashasya","sequence":"first","affiliation":[{"name":"Department of Urology, SMS Medical College &amp; Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urology, SMS Medical College &amp; Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Priyadarshi","sequence":"additional","affiliation":[{"name":"Department of Urology, SMS Medical College &amp; Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.041"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09800.x"},{"issue":"5","key":"e_1_3_2_4_2","first-page":"1036","article-title":"Long-term follow-up of urethroplasty for anterior urethral strictures","volume":"198","author":"Barbagli G","year":"2017","unstructured":"Barbagli G, Kulkarni S, Fossati N, et al. Long-term follow-up of urethroplasty for anterior urethral strictures. J Urol 2017; 198(5): 1036\u20131043.","journal-title":"J Urol"},{"issue":"1","key":"e_1_3_2_5_2","first-page":"57","article-title":"Lichen sclerosus and urethral stricture disease","volume":"44","author":"Kulkarni S","year":"2017","unstructured":"Kulkarni S, Barbagli G, Kirpekar D, et al. Lichen sclerosus and urethral stricture disease. Urol Clin North Am 2017; 44(1): 57\u201366.","journal-title":"Urol Clin North Am"},{"issue":"3","key":"e_1_3_2_6_2","first-page":"497","article-title":"Lichen sclerosus and urethral strictures: a review","volume":"83","author":"Nikolavsky D","year":"2014","unstructured":"Nikolavsky D, Blakely SA, Hadley HR. Lichen sclerosus and urethral strictures: a review. Urology 2014; 83(3): 497\u2013504.","journal-title":"Urology"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.042945"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.06.027"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000340"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000340"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251388207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03915603251388207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251388207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:34:58Z","timestamp":1775820898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03915603251388207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/03915603251388207"],"URL":"https:\/\/doi.org\/10.1177\/03915603251388207","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"value":"0391-5603","type":"print"},{"value":"1724-6075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]}}}