{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:40:15Z","timestamp":1794271215064,"version":"4.9.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    In recent years, healthcare strategies have increasingly emphasized a holistic and comprehensive approach in patient management that extends beyond the treatment of isolated physical symptoms. In this context, the use of nutraceuticals has gained interest as a complementary approach, particularly in managing chronic conditions and age-related disorders, such as lower urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH). A new dietary supplement, contains a blend of bio-active compounds (Drolessano\n                    <jats:sup>\u00ae<\/jats:sup>\n                    )\u2014including lycopene, sulforaphane, silymarin, glutathione, escine, tryptophan, and green tea extract\u2014has been introduced in Italian pharmacopeia as food supplements in urological and andrological diseases. Here, we aim to assess the effects of Drolessano\n                    <jats:sup>\u00ae<\/jats:sup>\n                    on serum prostate-specific antigen (PSA) levels and urinary symptoms in individuals with BPH. Fifty-five men presenting with elevated PSA values and mild lower urinary tract symptoms (International Prostate Symptom Score [IPSS]\u2009&lt;\u20097) were recruited in this pilot study. All enrolled patients underwent Drolessano\n                    <jats:sup>\u00ae<\/jats:sup>\n                    one tablet daily for 6\u2009months. PSA concentrations and IPSS scores were recorded at baseline (T0), at 3\u2009months (T1), and at the end of the treatment period (T2). Data at the follow-up has been compared with those at baseline. Patients enrolled experienced a statistical significance average PSA declined from 4.8 to 3.7\u2009ng\/mL (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.003), as well as in improvement of quality of life, tested by patient reported outcomes. The supplement was generally well tolerated, and no serious adverse effects were reported during the study period. These preliminary data suggest that Drolessano\n                    <jats:sup>\u00ae<\/jats:sup>\n                    may offer a supportive benefit in the management of BPH, particularly with respect to reducing PSA levels and improvement quality of life. Otherwise, controlled trials with larger sample sizes are needed to substantiate these findings and to better understand the underlying mechanisms of action.\n                  <\/jats:p>","DOI":"10.1177\/03915603251408298","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:38:23Z","timestamp":1767616703000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prostate health supporting by a novel nutraceutical compound with antioxidant property: Results from a pilot study"],"prefix":"10.1177","volume":"93","author":[{"given":"Claudio","family":"Marino","sequence":"first","affiliation":[{"name":"Department of Urology, Federico II University of Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Magliocchetti","sequence":"additional","affiliation":[{"name":"Department of Urology, Federico II University of Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Di Lieto","sequence":"additional","affiliation":[{"name":"Department of Urology, Federico II University of Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Cione","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vocca","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Pharmacology and Pharmacovigilance, AOU Dulbecco and Department of Health Science, University of Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-2933","authenticated-orcid":false,"given":"Tommaso","family":"Ceccato","sequence":"additional","affiliation":[{"name":"Department of Urology, Santa Chiara Regional Hospital, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Botti","sequence":"additional","affiliation":[{"name":"Department of Urology, Santa Chiara Regional Hospital, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Urologic Unit, Di Venere Hospital, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Operative Unit of Clinical Pharmacology and Pharmacovigilance, AOU Dulbecco and Department of Health Science, University of Catanzaro, Italy"},{"name":"Medifarmagen, University of Catanzaro and Renato Dulbecco Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-3526","authenticated-orcid":false,"given":"Tommaso","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology, Santa Chiara Regional Hospital, Trento, Italy"},{"name":"Interdepartmental Centre of Medical Sciences (CISMed), University of Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214637"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12935"},{"key":"e_1_3_2_4_2","unstructured":"SIA Drolessano- Societ\u00e0 Italiana di Andrologia https:\/\/www.siabc.it\/drolessano (accessed 9 December 2024)."},{"key":"e_1_3_2_5_2","first-page":"50","article-title":"Evidence-based herbal treatments in liver diseases","volume":"5","author":"Mancak M","year":"2024","unstructured":"Mancak M, Altintas D, Balaban Y, et al. Evidence-based herbal treatments in liver diseases. Hepatol Forum 2024; 5: 50\u201360.","journal-title":"Hepatol Forum"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091130"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0307-y"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.05.021"},{"key":"e_1_3_2_10_2","first-page":"1","article-title":"The anti-cancer activity of lycopene: a systematic review of human and animal studies","volume":"14","author":"Kapa\u0142a A","year":"2022","unstructured":"Kapa\u0142a A, Szlendak M, Motacka E. The anti-cancer activity of lycopene: a systematic review of human and animal studies. Nutrition 2022; 14: 1\u201314.","journal-title":"Nutrition"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179968"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S297501"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/uro3030022"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4503"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12395"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.12636"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21198"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080897"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000210"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.157065"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110459"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244376"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01225-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086979"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.9.1399"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10030126"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S207720"},{"key":"e_1_3_2_28_2","first-page":"8","article-title":"Extremely elevated prostate-specific antigen in acute prostatitis: a case report","volume":"15","author":"Nepal A","year":"2023","unstructured":"Nepal A, Sharma P, Bhattarai S, et al. Extremely elevated prostate-specific antigen in acute prostatitis: a case report. Cureus 2023; 15: 8.","journal-title":"Cureus"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871523015666160915154443"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570163817666201229121033"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2019.3.139"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-024-4100-2"},{"key":"e_1_3_2_33_2","first-page":"351","article-title":"A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats","volume":"356","author":"Hsiao G","year":"2004","unstructured":"Hsiao G, Fong TH, Tzu NH, et al. A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats. In Vivo 2004; 356: 351\u2013356.","journal-title":"In Vivo"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1128"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60060999"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192316193"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/03915603241258697"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251408298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03915603251408298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251408298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:35:09Z","timestamp":1775820909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03915603251408298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/03915603251408298"],"URL":"https:\/\/doi.org\/10.1177\/03915603251408298","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"value":"0391-5603","type":"print"},{"value":"1724-6075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}