{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:10:29Z","timestamp":1775823029646,"version":"3.50.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100015731","name":"bayer yakuhin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Differentiating prostate cancer (PCa) in the transition zone (TZ) from benign prostate hyperplasia based on MRI findings has often been challenging. This study aims to evaluate the utility of a quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE\u2013MRI) using time-resolved angiography with stochastic trajectories\u2012volumetric interpolated breath-hold examination (TWIST\u2013VIBE) in cases of PCa in the TZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, we examined the biopsy findings of 23 patients with elevated prostate-specific antigen (PSA) levels (&gt;4\u2009ng\/mL) who underwent DCE\u2013MRI using TWIST\u2013VIBE. The parameters analyzed included K\n                      <jats:sup>trans<\/jats:sup>\n                      (the transfer constant), K\n                      <jats:sup>ep<\/jats:sup>\n                      (the reflux constant), Ve (the extravascular extracellular volume fraction), and the initial area under the curve on the Tissue 4D platform (Siemens).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The quantitative analysis revealed no significant differences in any of the examined parameters between positive and negative PCa in the TZ. Additionally, there were no significant differences among the histological grades of PCa in the TZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A quantitative analysis of findings obtained by DCE\u2013MRI using TWIST\u2013VIBE did not yield statistically significant results for differentiating the status of PCa in the TZ. However, DCE\u2013MRI using TWIST\u2013VIBE, an ultrafast DCE\u2013MRI technique, may be useful for evaluating tumor hemodynamics and assessing the size dependence of prostate cancer lesions in the transition zone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603251414596","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T01:26:51Z","timestamp":1769477211000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative analysis of dynamic-contrast MRI for the assessment of prostate cancer in the transition zone"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-4404","authenticated-orcid":false,"given":"Mariko","family":"Doai","sequence":"first","affiliation":[{"name":"Department of Radiology, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ippei","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohsuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiya","family":"Hirata","sequence":"additional","affiliation":[{"name":"Section of Radiological Technology, Department of Medical Technology, Kanazawa Medical University Hospital, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhito","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Kanazawa Medical University, Kahoku, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyae079"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-015-0589-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2017.08.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6861"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.rev.2021-0157"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06608-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2015.11.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24062"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2020190207"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1329"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265056"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-016-0720-8"},{"key":"e_1_3_2_16_2","article-title":"Reproducibility of dynamic contrast-enhanced MRI in renal cell carcinoma: a prospective analysis on intra- and interobserver and scan\u2013rescan performance of pharmacokinetic parameters","volume":"94","author":"Wang H","year":"2015","unstructured":"Wang H, Su Z, Ye H, et al. Reproducibility of dynamic contrast-enhanced MRI in renal cell carcinoma: a prospective analysis on intra- and interobserver and scan\u2013rescan performance of pharmacokinetic parameters. Medicine 2015; 94: e1529.","journal-title":"Medicine"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249532"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.03.015"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251414596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03915603251414596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603251414596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:34:46Z","timestamp":1775820886000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03915603251414596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/03915603251414596"],"URL":"https:\/\/doi.org\/10.1177\/03915603251414596","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"value":"0391-5603","type":"print"},{"value":"1724-6075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}