{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:48Z","timestamp":1791414108826,"version":"4.3.3"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Holmium laser enucleation of the prostate (HoLEP) is considered one of the option for the treatment of men with bothersome lower urinary tract symptoms (LUTS) related to Benign Prostatic Obstruction (BPO). HoLEP is performed with 26Ch instruments, which can cause urethral trauma, strictures, transient incontinence. Recent miniaturized 22Ch tools (MiLEP) aim to reduce morbidity without compromising efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a prospective multicenter study on men underwent MiLEP. Preoperative assessment included IPSS, uroflowmetry, PSA, prostate volume and urinary continence. The MiLEP were performed en-bloc with early apical release. Follow-up assessed subjective and objective outcomes together with complications and patient satisfaction. Clinical success was defined as Trifecta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Sixty-five men were enrolled. No major intraoperative complications occurred; median catheterization and hospital stay were 2 and 2\u2009days, respectively. Overall complication rate was 18.4%, mostly Clavien\u2013Dindo grade I\u2013II. Late complications were urethral stricture in 4.6% and persistent stress incontinence in 1.5%. At 12\u2009months, mean IPSS, IPSS QoL, Qmax, PSA significantly improved (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Overall satisfaction was very high (96.8%). Trifecta was achieved in 61.5% of cases. Logistic regression identified lower pre operative Qmax as the only predictor of Trifecta achievement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MiLEP appears feasible and safe in this preliminary series, with perioperative and functional outcomes consistent with enucleation-like goals. Significant improvements in symptom scores, flow rate and PSA were sustained at 12\u2009months with low morbidity and high continence preservation. Larger appropriate trials and longer follow up are needed to confirm our data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603261440245","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:42:16Z","timestamp":1777470136000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Miniaturized laser enucleation of the prostate (MiLEP) is feasible and safe: 12-month follow-up, real-life, prospective multicenter study"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2719","authenticated-orcid":false,"given":"Luca","family":"Cindolo","sequence":"first","affiliation":[{"name":"Department of Urology, Centro Urologico Europeo CURE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6678-6868","authenticated-orcid":false,"given":"Marco Domenico","family":"Salvaggio","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Urologico Europeo CURE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare Mario","family":"Scoffone","sequence":"additional","affiliation":[{"name":"Department of Urology, Cottolengo Hospital, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Maria","family":"Cracco","sequence":"additional","affiliation":[{"name":"Department of Urology, Cottolengo Hospital, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis Goumas","family":"Kartalas","sequence":"additional","affiliation":[{"name":"Department of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Orecchia","sequence":"additional","affiliation":[{"name":"Urology Unit, Fondazione PTV Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-5822","authenticated-orcid":false,"given":"Roberto","family":"Castellucci","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Urologico Europeo CURE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Dibitetto","sequence":"additional","affiliation":[{"name":"Urocenter, Clinica Nuova Villa Claudia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Urology, Centro Urologico Europeo CURE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Cornu J Gacci M Hashim H. EAU guidelines on non-neurogenic male lower urinary tract symptoms (LUTS) https:\/\/uroweb.org\/guidelines\/management-of-non-neurogenic-male-luts (2025 accessed 14 December 2025)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00743-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00831-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00677-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00730-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04308-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2024.0039"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00841-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1345-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolvj.2022.100146"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04562-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12414"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24790"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.70016"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-025-05785-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02671-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.12954\/PI.14066"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0476-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.220042"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00669-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00833-z"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-022-00616-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2014.0093"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0391560318758195"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0350"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14103410"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2025.03.012"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603261440245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03915603261440245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03915603261440245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:34:59Z","timestamp":1789619699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03915603261440245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/03915603261440245"],"URL":"https:\/\/doi.org\/10.1177\/03915603261440245","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"value":"0391-5603","type":"print"},{"value":"1724-6075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}