{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:40:09Z","timestamp":1792309209887,"version":"4.4.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Urethral stricture (US) disease frequently recurs after direct visual internal urethrotomy (DVIU). This study investigated the prognostic value of serum creatinine, estimated glomerular filtration rate (eGFR), and the hemoglobin\/creatinine (Hgb\/Cre) ratio for predicting 12-month recurrence in short-segment bulbar US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort of 237 patients undergoing DVIU for isolated bulbar US\u2009&lt;2\u2009cm between 2012 and 2024 was analyzed. Demographics, comorbidities, laboratory parameters, and uroflowmetry were recorded. Renal function markers (creatinine, eGFR) and Hgb\/Cre ratio were evaluated using receiver operating characteristic (ROC) analysis, Kaplan\u2013Meier survival curves, and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Recurrence occurred in 103 patients (43.5%) within 12\u2009months (median: 6\u2009months). Patients with recurrence had higher creatinine (1.10 vs 0.99\u2009mg\/dL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lower eGFR (74.0 vs 88.0\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lower Hgb\/Cre ratios (12.13 vs 14.28,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). Endoscopic surgery\u2013related etiology was strongly associated with recurrence (70.8% vs 47.0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001), whereas age, hemoglobin, Qmax, and PVR showed no significant relationship. In multivariable models, elevated creatinine (OR 3.47, 95% CI 1.82\u20136.60), reduced Hgb\/Cre ratio (OR 0.90, 95% CI 0.85\u20130.95), and lower eGFR (OR 0.975, 95% CI 0.964\u20130.987) independently predicted recurrence. Kaplan\u2013Meier analysis demonstrated significantly higher recurrence in patients with creatinine\u2009\u2a7e\u20091.02\u2009mg\/dL, eGFR\u2009\u2a7d\u200980.5\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , and Hgb\/Cre ratio\u2009\u2a7d\u200913.26.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Elevated serum creatinine, reduced eGFR, and a lower Hgb\/Cre ratio are independent predictors of 12-month recurrence following DVIU for short-segment bulbar US. Demographic and uroflowmetric parameters showed limited predictive value, whereas iatrogenic etiology markedly increased recurrence risk. Incorporating renal function markers into risk stratification may guide patient selection and support timely consideration of urethroplasty or drug-coated balloon dilatation (Optilume) in high-risk individuals. Prospective multicenter studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603261447735","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:08:02Z","timestamp":1777900082000},"page":"796-804","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Creatinine and hemoglobin\/creatinine ratio as predictors of 12-month recurrence after direct visual internal urethrotomy for short-segment (&lt;2\u2009cm) bulbar urethral strictures"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-919X","authenticated-orcid":false,"given":"R\u0131dvan","family":"Kayar","sequence":"first","affiliation":[{"name":"Department of Urology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"Kayar","sequence":"additional","affiliation":[{"name":"Department of Urology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u015fim","family":"\u00c7a\u00e7an","sequence":"additional","affiliation":[{"name":"Department of Urology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-9278","authenticated-orcid":false,"given":"Emre","family":"Tokuc","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical Park Goztepe Hospital Complex, Bahcesehir University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin \u0130shak","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Urology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"209","article-title":"Epidemiology of urethral strictures","volume":"3","author":"Alwaal A","year":"2014","unstructured":"Alwaal A, Blaschko SD, McAninch JW, et al. 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