{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:40:08Z","timestamp":1792309208542,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate the outcomes of the Rez\u016bm procedure in men aged 50\u2009years or younger, focusing on changes in urinary symptoms and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective registry was created as part of the International Rez\u016bm Registry database at two high-volume centers. The study reviewed data from patients monitored between April 2019 and August 2024. All patients aged 50\u2009years or younger had their baseline medical and BPH history recorded, which included uroflowmetry measurements (Qmax and PVR) and validated questionnaires such as the International Prostate Symptom Score (IPSS), IPSS Quality of Life (QoL), Benign Prostatic Hyperplasia Impact Index (BPHII) and International Index of Erectile Function-15 (IIEF-15). Data were collected at baseline and at 3, 6, and 12\u2009months following the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fourteen patients were included, with a mean age of 49.6\u2009years (SD 1.05). The mean baseline prostate volume was 54.3\u2009cc (SD: 22.0). At baseline, the mean IPSS was 24.3\u2009\u00b1\u20095.9, which significantly improved to 10.5\u2009\u00b1\u20095.8 at 6\u2009months and 11.6\u2009\u00b1\u20095.4 at 12\u2009months. The IPSS QoL score improved from 4.8\u2009\u00b1\u20090.9 at baseline to 2.4\u2009\u00b1\u20091.7 at 12\u2009months. Qmax increased from 7.9\u2009\u00b1\u20094.5\u2009mL\/s to 17.8\u2009\u00b1\u20096.1\u2009mL\/s at 12\u2009months. PVR decreased from 197.6\u2009\u00b1\u2009270.2\u2009mL to 51\u2009\u00b1\u200977\u2009mL at 12\u2009months. IIEF scores showed no significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The Rez\u016bm procedure demonstrates significant efficacy in improving urinary symptoms and quality of life in men under 50.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03915603261452348","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:36:08Z","timestamp":1780410968000},"page":"699-704","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Rez\u016bm therapy in young men: A multi-center study"],"prefix":"10.1177","volume":"93","author":[{"given":"Sagi","family":"Shprits","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2867-9723","authenticated-orcid":false,"given":"Mario","family":"Bitar","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Buksh","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Hammoud","sequence":"additional","affiliation":[{"name":"American University of Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Bhojani","sequence":"additional","affiliation":[{"name":"Division of Urology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Plainview Hospital, Smith Institute of Urology, No0rthwell Health, Syosset, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Zorn","sequence":"additional","affiliation":[{"name":"BPH Canada, Prostate Surgical Institute, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cindolo","sequence":"additional","affiliation":[{"name":"Urology Department, Hesperia Hospital, CUrE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Urology Department, Hesperia Hospital, CUrE Group, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lajkosz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Elterman","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Parsons JK. Benign prostatic hyperplasia and male lower urinary tract symptoms: epidemiology and risk factors. Curr Bladder Dysfunct Rep 2010; 5(4): 212\u2013218. https:\/\/doi.org\/10.1007\/s11884-010-0067-2","DOI":"10.1007\/s11884-010-0067-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Engstr\u00f6m G Henningsohn L Walker-Engstr\u00f6m ML et al. Impact on quality of life of different lower urinary tract symptoms in men measured by means of the SF 36 questionnaire. Scand J Urol Nephrol 2006; 40(6): 485\u2013494. https:\/\/doi.org\/10.1080\/00365590600830862","DOI":"10.1080\/00365590600830862"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Stroup SP Palazzi-Churas K Kopp RP et al. Trends in adverse events of benign prostatic hyperplasia (BPH) in the USA 1998 to 2008. 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Rezum water vapor thermal therapy for treatment of lower urinary tract symptoms: a retrospective single-centre analysis from a German high-volume centre. PLoS One 2023; 18(1): e0279883. https:\/\/doi.org\/10.1371\/journal.pone.0279883","DOI":"10.1371\/journal.pone.0279883"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Tayeb W Azhar RA Subahi M et al. Rez\u016dm water vaporization therapy versus transurethral resection of the prostate in the management of refractory urine retention: matched pair comparative multicenter experience. World J Urol 2024; 42(1): 48. https:\/\/doi.org\/10.1007\/s00345-023-04739-8","DOI":"10.1007\/s00345-023-04739-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"McVary KT Gittelman MC Goldberg KA et al. Final 5-Year outcomes of the Multicenter Randomized Sham-controlled trial of a water vapor thermal therapy for treatment of moderate to severe lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 2021; 206(3): 715\u2013724. https:\/\/doi.org\/10.1097\/JU.0000000000001778","DOI":"10.1097\/JU.0000000000001778"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"McVary KT Rogers T Roehrborn CG. Rez\u016bm water vapor thermal therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia: 4-Year results from randomized controlled study. Urology 2019; 126: 171\u2013179. https:\/\/doi.org\/10.1016\/j.urology.2018.12.041","DOI":"10.1016\/j.urology.2018.12.041"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Alcina EL Arjona MF Guzm\u00e1n EF et al. Expert consensus on Rez\u016bm\u2122: Indications surgical technique and postoperative care. BJUI Compass 2025; 6(2): e491. https:\/\/doi.org\/10.1002\/bco2.491","DOI":"10.1002\/bco2.491"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Elterman D Bhojani N Vannabouathong C et al. Rez\u016bm therapy for \u2a7e80-mL benign prostatic enlargement: a large multicentre cohort study. BJU Int 2022; 130(4): 522\u2013527. https:\/\/doi.org\/10.1111\/bju.15753Available from.","DOI":"10.1111\/bju.15753"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Bizzarri FP Campetella M Ragonese M et al. The role of alternative medicine and complimentary therapies in urologic disease: new horizons. Urologia 2024; 91(4): 641\u2013646. https:\/\/doi.org\/10.1177\/03915603241258697","DOI":"10.1177\/03915603241258697"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Elterman D Bhojani N Vannabouathong C et al. Large multi-center prospective registry of Rez\u016bm water vapor therapy for benign prostatic hyperplasia. Urology 2022; 165: 261\u2013267. https:\/\/doi.org\/10.1016\/j.urology.2022.02.001","DOI":"10.1016\/j.urology.2022.02.001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"Arezki A Sadri I Couture F et al. Reasons to go for Rez\u016bm steam therapy: an effective and durable outpatient minimally invasive procedure. World J Urol 2021; 39(7): 2307\u20132313. https:\/\/doi.org\/10.1007\/s00345-020-03457-9","DOI":"10.1007\/s00345-020-03457-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"Nguyen DD Li T Ferreira R et al. Ablative minimally invasive surgical therapies for benign prostatic hyperplasia: a review of Aquablation Rezum and transperineal laser prostate ablation. Prostate Cancer Prostatic Dis 2024; 27(1): 22\u201328. https:\/\/doi.org\/10.1038\/s41391-023-00669-z","DOI":"10.1038\/s41391-023-00669-z"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"Wolters M Krastel M Winkler T et al. Real-world experience of water vapour therapy (Rezum) in patients with benign prostatic enlargement: a retrospective single-center study. 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